Tests aspirin to prevent pregnancy complications in women with chronic high blood pressure
Tests aspirin 150 mg daily against placebo in pregnant women with high blood pressure.
Plain-language title generated from the registry record
Registry title: Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy
Key facts
- Where
- Bordeaux, Caen, Clamart, Colombes, Créteil, Dijon, Le Kremlin-Bicêtre, Lille, Lyon, Marseille, Nancy, Nantes, Paris, Poissy, Saint-Etienne, Toulouse, and Tours, FranceSee the 20 sites
- Phase
- Phase 3
Where in France
- CHU BordeauxBordeaux, FranceTaking people
- CHU CaenCaen, FranceNo longer taking part
- CHU Antoine Béclère, AP-HPClamart, FranceTaking people
- Hôpital Louis Mourier, AP-HPColombes, FranceTaking people
- Centre Hospitalier Intercommunal de CréteilCréteil, FranceTaking people
- CHU DijonDijon, FranceTaking people
- CHU Bicêtre, AP-HPLe Kremlin-Bicêtre, FranceTaking people
- CHRU LilleLille, FranceNot yet recruiting
- Chu LyonLyon, FranceTaking people
- Hôpital St JosephMarseille, FranceNo longer taking part
- CHRU NancyNancy, FranceNo longer taking part
- CHU NantesNantes, FranceTaking people
- CHU Cochin- Port Royal, AP-HPParis, FranceTaking people
- CHU Robert Débré, AP-HPParis, FranceTaking people
- CHU TenonParis, FranceTaking people
- Hôpital Trousseau, AP-HPParis, FranceTaking people
- Ch PoissyPoissy, FranceTaking people
- Chu St-EtienneSaint-Etienne, FranceTaking people
- CHU ToulouseToulouse, FranceNot yet recruiting
- CHU ToursTours, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Intercommunal Creteil
- Trial code
- NCT04356326
- Record updated
- 12 June 2026
- Original description
A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic hypertension.Read full original descriptionShow less
Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy, a Multicenter Prospective Randomized Double-blind Placebo-controlled Trial.
A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic hypertension.
Inclusion: Pregnant patient between 10 and 19 weeks of gestation + 6 days; Chronic hypertension, whether treated or not, know before pregnancy or diagnosed before randomization; Singleton pregnancy; Signed the written informed consent; Affiliation to social security.
Exclusion: Patient receiving aspirin for another indication outside pregnancy,; ---Medical history requiring anticoagulation (antiphospholipid syndrome, deep vein thromboembolic disease, pulmonary embolism, atherothrombosis, patient with mechanical heart valves),; Active bleeding,; History of severe PE with delivery < 34 weeks of gestation,; Hypersensitivity to salicylates such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs),; Hemostasis disorders, including hemophilia (with thrombocytopenia); Any constitutional or acquired hemorrhagic disease, (including digestive hemorrhages, history of hemorrhagic stroke and thrombocytopenia; Patients with psychiatric follow-up, poor understanding of French or cognitive problems,; Duodenal ulcer,; Severe renal impairment,; Severe hepatic insufficiency,; Severe cardiac impairment,; Platelet count lower than 100,000 cells/microliter (dosage less than 6 months old),; Human immunodeficiency virus, or hepatitis B virus, or hepatitis C virus positive serum,; Patients with known glucose-6-phosphate dehydrogenase deficiency,; Age <18 years old,; Patient with significant proteinuria (> 300mg/24 hours or a proteinuria/creatininuria ratio ≥ 30mg/mmol),; Patient included in another interventional study which could interfere with the results of the study,; Women under the protection of justice,; Gout,.