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Taking people in United StatesNo phase

Tests MRI-guided radiation therapy in several cancers

Tests MRI-guided radiation for cancers including gastric, breast, and bladder cancer.

Key facts

Who runs it
Brigham and Women's Hospital
Where
Boston, United StatesSee the 2 sites
Trial code
Registry title
CONFIRM: Magnetic Resonance Guided Radiation Therapy
Status
Recruiting
People taking part
70 people, planned
Started
1 May 2021
Expected to end
18 Jun 2029
Type of study
Interventional, 5 groups
Treatments tested
  • Viewray MRIdian® Linac
Record updated
9 February 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a confirmed cancer that needs radiation. The radiation is guided by MRI scans.

Age
18 years or older
Sex
All sexes can join.
Disease stage
A cancer confirmed by tissue or cell tests that needs radiation. Extra rules apply for each cancer type group.

Main reasons for not taking part

  • Allergic reaction to gadolinium-based contrast given into a vein
  • Severe claustrophobia or anxiety
  • Cannot have an MRI
  • Cannot understand or sign the written consent form
  • Any extra exclusion rules of the specific cancer group

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

  • Participants must have histologically or cytologically confirmed malignancy requiring radiation
  • Age 18 years of older
  • ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
  • Ability to understand and the willingness to sign a written informed consent document
  • Any further criteria listed in the specific disease site cohort

Who cannot take part

  • History of allergic reactions attributed to gadolinium-based IV contrast; -- Note: If patient will not receive contrast, this is not applicable and kidney function will not affect eligibility
  • Any other exclusion criteria listed in the specific disease site cohort
  • Severe claustrophobia or anxiety
  • Participants who cannot undergo an MRI

Where in United States

  • Brigham & Women's HospitalBoston, United StatesContact: Raymond Mak, MDTaking people
  • Dana-Farber Cancer InstituteBoston, United StatesContact: Raymond Mak, MDTaking people

About the trial

What the trial wants to find out

This research is being done to determine the safety and feasibility of using a type of radiation guided by magnetic resonance imaging (MRI) and chemotherapy to treat patients with gastric and breast cancer. The name of the radiation machine involved in this study is the MRIdian Linear Accelerator.

The 5 groups in the trial

  • Phase I - Gastric CancerTreatment being tested

    The research study procedures include: * Screening for eligibility * Study treatment including evaluations * MR-image guided radiation will be administered per disease site standards. * Follow up visits * Questionnaires

    Treatment: Viewray MRIdian® Linac

  • Phase I - Breast CancerTreatment being tested

    The research study procedures include: * Screening for eligibility * Study treatment including evaluations * MR-image guided radiation will be administered per disease site standards. * Follow up visits * Questionnaires

    Treatment: Viewray MRIdian® Linac

  • Phase I - Mantle Cell LymphomaTreatment being tested

    The research study procedures include: * Screening for eligibility * Study treatment including evaluations * MR-image guided radiation will be administered per disease site standards. * Follow up visits * Questionnaires

    Treatment: Viewray MRIdian® Linac

  • Phase I - LarynxTreatment being tested

    The research study procedures include: * Screening for eligibility * Study treatment including evaluations * MR-image guided radiation will be administered per disease site standards. * Follow up visits * Questionnaires

    Treatment: Viewray MRIdian® Linac

  • Phase I - BladderTreatment being tested

    The research study procedures include: * Screening for eligibility * Study treatment including evaluations * MR-image guided radiation will be administered per disease site standards. * Follow up visits * Questionnaires

    Treatment: Viewray MRIdian® Linac

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Clinical Onboard Utilization of Image Guided Radiation Therapy With Magnetic Resonance (CONFIRM): A Master Protocol
Plain-language title
Tests MRI-guided radiation therapy in several cancersGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
9 February 2026