Under construction – not a live service
Sign in
Taking people in PolandNo phase

Using a resting heart pressure test to guide bypass surgery planning

Compares a resting pressure test with angiography to guide bypass surgery in coronary artery disease.

Key facts

Who runs it
Diagram B.V.
Where
Katowice, PolandSee the siteAlso in 2 other countries, 3 sites
Trial code
Registry title
Resting Full-cycle Flow Ratio (RFR) Versus Angiography to Guide Revascularization Strategy in Patients Undergoing Coronary Artery By-pass Grafting (CABG)
Status
Recruiting
People taking part
500 people, planned
Started
3 Feb 2020
Expected to end
30 Jun 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • RFR guided CABG
  • Angio guided CABG
Record updated
1 February 2024

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults who are going to have coronary artery bypass surgery (CABG). It compares guiding the surgery with an RFR measurement against angiography alone.

Age
18 years or older
Sex
All sexes can join.
Disease stage
Coronary artery disease, with planned CABG surgery.
Earlier treatment
People who had a previous CABG cannot join.

Main reasons for not taking part

  • Previous CABG
  • Severe valve disease needing an operation at the same time
  • Remaining coronary narrowing of more than 50% beyond the graft connection
  • Left ventricular ejection fraction below 30%
  • Life expectancy under 2 years

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • All patients between 18 or older undergoing CABG
  • Patients willing and capable to provide written informed consent

Who cannot take part

  • Previous CABG
  • Concomitant severe valvular disease intervention
  • Known transmural myocardial infarction
  • Documented microvascular disease
  • Left ventricular ejection fraction <30%
  • Life expectancy <2 years
  • Remaining (expected) coronary stenosis of > 50% diameter stenosis distally to graft anastomosis
  • RFR/FFR measurement judged impossible
  • Participation in other investigational clinical trials

Where in Poland

Also in 2 other countries, 3 sites

  • Medical University of SilesiaKatowice, PolandContact: Pawel Gasior, MDTaking people

About the trial

What the trial wants to find out

Different trials have shown that fractional flow reserve (FFR) could successfully guide revascularization in patients undergoing percutaneous coronary intervention (PCI).

Read full original descriptionShow less

It is conceivable that a similar revascularization guidance could be useful also for surgical revascularization i.e. coronary by-pass graft (CABG). Experience learns that grafts placed on vessels with hemodynamically non-significant stenosis often occlude due to competitive antegrade flow.

Resting full-cycle Flow Ratio (RFR) is a measurement performed to evaluate the hemodynamic severity of coronary stenosis. Differently from FFR which is a measurement performed in maximal hyperemia, the RFR is a measurement that is performed in rest and therefore may predict better than FFR the baseline equilibriums that could lead to graft failure, while it has similar capacity to identify hemodynamically significant stenosis as FFR. It is unknown whether RFR guided CABG revascularization is superior as compared to angiography alone.

The 2 groups in the trial

  • angiography guided CABGExisting treatment, for comparison

    Treatment: Angio guided CABG

  • RFR guided CABGTreatment being tested

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Resting Full-cycle Flow Ratio (RFR) Versus Angiography to Guide Revascularization Strategy in Patients Undergoing Coronary Artery By-pass Grafting (CABG): RFR-CABG Trial
Plain-language title
Using a resting heart pressure test to guide bypass surgery planningGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
1 February 2024