Eye Imaging to Study Retina Changes in People With Memory Impairment
Uses eye scans to look at retina blood vessels in adults with memory problems.
Plain-language title generated from the registry record
Registry title: OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Hôpital Fondation A. de RothschildParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondation Ophtalmologique Adolphe de Rothschild
- Trial code
- NCT04389437
- Record updated
- 30 October 2026
- Original description
Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases.Read full original descriptionShow less
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases.
These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD.
No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.
Inclusion: Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint.
Exclusion: history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis); history of retinal pathology; history of taking ethambutol for more than 2 months; history of takingsynthetic antimalarial for more than 2 years; pregnant or lactating women; ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5 diopters on the cylinder; Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) <10 for patients and 26 for accompanying persons; MRI contraindication (for patients only).