Brain imaging and memory tests to study thinking problems in multiple sclerosis
Uses brain MRI scans and thinking tests to study multiple sclerosis in adults.
Key facts
- Who runs it
- University of Wisconsin, Madison
- Where
- Madison, United StatesSee the site
- Trial code
- Registry title
- Macromolecular Imaging of White and Gray Matter Pathology in Multiple Sclerosis
- Status
- Enrolling by invitation
- People taking part
- 75 people, planned
- Started
- 19 Nov 2021
- Expected to end
- Apr 2027
- Type of study
- Observational, 3 groups
- Treatments tested
- MRI
- Neuropsychological Testing
- Record updated
- 28 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 60 with clinically definite multiple sclerosis (MS). Healthy controls also take part.
- Age
- 18 to 60 years
- Sex
- All sexes can join.
- Disease stage
- Clinically definite MS.
- Earlier treatment
- No change in MS therapy in the last 6 months. At least 6 weeks since a relapse or corticosteroid use.
Main reasons for not taking part
- Cannot have an MRI
- Taking medicine that may affect thinking (such as donepezil, rivastigmine, adderall)
- History of significant alcohol or drug abuse
- Other brain or thinking disorders (stroke, Parkinson's disease, Alzheimer's disease, epilepsy)
- History of developmental or learning disability or attention-deficit/hyperactivity disorder
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Clinically definite MS
- Adult age 18 to 60
Who cannot take part
- Changes in MS therapy in the last 6 months
- Less than 6 weeks after relapse or corticosteroid use
- Currently taking medication that may affect cognition (e.g. donepezil, rivastigmine, adderall)
- History of significant alcohol or drug abuse
- Confounding neurological or cognitive disorders or deficits (stroke, Parkinson's disease, Alzheimer's disease, epilepsy)
- History of developmental or learning disability or attention-deficit/hyperactivity disorder.\
- history of alcohol/drug abuse
- history of migraines
- developmental or learning disability/attention-deficit/hyperactivity disorder
- Contraindication to MRI
- Current or recent significant migraines
- Sensory or physical impairments that might interfere significantly with cognitive testing
- currently pregnant/breastfeeding
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Where in United States
- University of Wisconsin - MadisonMadison, United StatesNo longer taking part
About the trial
What the trial wants to find out
The overall purpose of this research is to determine whether new macromolecular measures optimized for whole brain (gray matter and white matter) magnetic resonance imaging (MRI), predict neuro-cognitive impairment in multiple sclerosis (MS) patients.
The 3 groups in the trial
- Cognitive Impairment
Adults diagnosed with MS that have evidence of cognitive decline.
Treatment: MRI and Neuropsychological Testing
- No Cognitive Impairment
Adults diagnosed with MS that have no evidence of cognitive decline.
Treatment: MRI and Neuropsychological Testing
- Healthy Controls
Healthy adult volunteers will form a control group matched for age, gender, education, handedness
Treatment: MRI
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Macromolecular Imaging of White and Gray Matter Pathology in Multiple Sclerosis
- Plain-language title
- Brain imaging and memory tests to study thinking problems in multiple sclerosisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT04415372, who can take part
- Record updated
- 28 April 2026