Frontlight ResearchEarly access
CompletedPhase 4
Corneal Crosslinking Treatment Study
Key facts
- Who runs it
- Region Skane
- Where
- Sweden1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- Phase
- Phase 4
- People taking part
- 54 people enrolled
- Started
- 23 May 2017
- Ended
- 19 Nov 2024
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Corneal crosslinking: CXL (UVA 9mW/cm2)
- Isotonic riboflavin
- Hypotonic riboflavin
- Iontophoresis
- Record updated
- 22 November 2024
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 4 criteriaShow less
Who can take part
- Progress in keratoconic eye. We define progress as an increase in Kmax of 1.0 diopter in 1 year or 0.5 diopter in 6 months. This increase in Kmax will be accepted as progression if concomitant changes tomographic parameters
Who cannot take part
- Concurrent ocular infection or corneal disease other than keratoconus
- Treatment with Isotretinoin
- Pregnancy
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Three different protocols for inducing corneal crosslinks in subjets with progressive keratoconus will be evaluated in this randomised clinical study.
The 3 groups in the trial
- Isotonic riboflavinExisting treatment, for comparison
CXL (UVA 9mW/cm2) treatment using isotonic riboflavin
Treatment: Corneal crosslinking: CXL (UVA 9mW/cm2) and Isotonic riboflavin
- Hypotonic riboflavinExisting treatment, for comparison
CXL (UVA 9mW/cm2) using hypotonic riboflavin
Treatment: Corneal crosslinking: CXL (UVA 9mW/cm2) and Hypotonic riboflavin
- IontophoresisExisting treatment, for comparison
Iontophoresis with Ricrolin with following CXL (UVA 9mW/cm2).
Treatment: Corneal crosslinking: CXL (UVA 9mW/cm2) and Iontophoresis
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Prospective Randomised Corneal Crosslinking Study
- Publications
- Record updated
- 22 November 2024