A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
Key facts
- Phase
- Phase 4
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 85 years old?
Source: NCT04432012, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Christian Candrian
- Trial code
- NCT04432012
- Record updated
- 11 September 2026
- Original description
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.Read full original descriptionShow less
Comparison of Perioperative Intravenous vs Periarticular Dexamethasone vs no Steroid Supplementation in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications in Patients Undergoing Primary Total Knee Arthroplasty for Knee Osteoarthritis - A Randomized Controlled Trial Clinical Study Protocol
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.
Inclusion: Patients undergoing unilateral primary TKA at the Ospedale Regionale di Lugano; Patients with a BMI >18.5 and <35; Patients able to provide informed consent and follow all the study procedures as indicated by the protocol; Informed Consent as documented by signature (Appendix Informed Consent Form).
Exclusion: Contraindications to steroids; Active steroid therapy; Presence of other clinically significant concomitant disease states (ASA IV); Known or suspected non-compliance, drug or alcohol abuse; Participation in another study with investigational drug within the 30 days preceding and during the present study; Previous enrolment into the current study; Uncontrolled diabetes mellitus; Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant; Revision TKA; Women who are pregnant or breast feeding; Enrolment of the investigator, his/her family members, employees and other dependent persons.