EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients
Key facts
- Who runs it
- Columbia University
- Where
- New York, United StatesSee the site
- Trial code
- Status
- Not yet recruiting
- People taking part
- 600 people, planned
- Started
- 1 Apr 2026
- Expected to end
- 31 Mar 2031
- Type of study
- Interventional, 4 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Alpha Optimization
- Emergence from anesthesia with Dexmedetomidine
- Record updated
- 7 January 2026
Who can take part
- Age
- 60 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Adults aged 60 years or over
- Has capacity to provide informed consent
- Undergoing elective non-cardiac surgery, which does not involve the head or neck, with planned volatile-based general anesthesia of expected duration of at least 2 hours
Who cannot take part
- Chronic pain with opioid requirement or concurrent use of enzyme inducers, e.g. carbamazepine, phenytoin,
- Illicit substance use or excessive alcohol intake
- Refusal by patient or case anesthesiologist responsible for patient's care
Where in United States
- Columbia University Irving Medical CenterNew York, United StatesContact: Paul S. Garcia, MD, PhDNot yet recruiting
About the trial
What the trial wants to find out
The investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.
The 4 groups in the trial
- Maintenance-Alpha Optimization / Wake from DexmedetomidineTreatment being tested
During the first randomization, participants randomized to intraoperative oscillatory EEG alpha optimization will receive individualized titration of anesthetic gas and opioids.
Treatment: Alpha Optimization and Emergence from anesthesia with Dexmedetomidine
- Maintenance-Alpha Optimization / Wake from SevofluraneExisting treatment, for comparison
During the first randomization, participants randomized to intraoperative oscillatory EEG alpha optimization will receive real-time monitoring of alpha recordings and individualized titration of desflurane and opioid. During the second randomization, participants randomized to standard emergence from volatile anesthesia will be woken up per standard practice.
Treatment: Alpha Optimization
- Maintenance-Routine Care / Wake from DexmedetomidineExisting treatment, for comparison
During the first randomization, participants randomized to standard of care will receive anesthesia per usual care with quantitative processed EEG index values and EEG wave forms.
Treatment: Emergence from anesthesia with Dexmedetomidine
- Maintenance-Routine Care / Wake from SevofluraneNo study treatment, for comparison
During the first randomization, participants randomized to standard of care will receive anesthesia per usual care with quantitative processed EEG index values and EEG wave forms. During the second randomization, participants randomized to standard emergence from volatile anesthesia will be woken up per standard practice.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 7 January 2026