Comparing Heart Stunning in Takotsubo Syndrome and Heart Attack
Compares temporary heart muscle weakness in takotsubo syndrome and heart attack patients.
Plain-language title generated from the registry record
Registry title: Stunning in Takotsubo Versus Acute Myocardial Infarction
Key facts
- Where
- Gothenburg, SwedenSee the site
Where in Sweden
- Department of Cardiology; Sahlgrenska University HospitalGothenburg, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Vastra Gotaland Region
- Trial code
- NCT04448639
- Record updated
- 12 December 2023
- Original description
The Stunning in Takotsubo versus Acute Myocardial Infarction (STAMI) StudyRead full original descriptionShow less
STAMI- Stunning in Takotsubo Versus Acute Myocardial Infarction
The Stunning in Takotsubo versus Acute Myocardial Infarction (STAMI) Study
Background: Acute myocardial stunning, herein defined as the reversible loss of myocardial function, occurs in both takotsubo syndrome (TS) and ST-elevation myocardial infarction (STEMI), and can be life-threatening in both conditions. However, despite typically having considerably more pronounced myocardial stunning, TS patients have better prognosis than patients with STEMI. Despite the different relationship between extent of myocardial stunning and prognosis in TS vs STEMI, no 'head-to-head' comparison of the myocardial stunning phenotypes in TS vs STEMI has been done.
Methods: The Stunning In Takotsubo and Acute Myocardial Infarction (STAMI) study is a single-center, prospective clinical study that will enroll 100 patients with STEMI and 25 patients with TS. Echocardiography, laboratory testing (including troponin and NTpro-BNP), and ECG will be done immediately after angiography and at days 1, 2, 3, 7, 14 and 30. The primary endpoint is the proportion of myocardial stunning that has resolved after 72 hours, as determined by echocardiography. Total myocardial stunning is defined as the extent of akinesia observed at day 0 that resolves by day 30.
Inclusion: STEMI or TS with planned coronary angiography within 12 hours from the onset of symptoms; Written consent.
Exclusion: Cardiogenic shock, defined as Killip class IV; Expected inability to comply with the protocol.