Checking troponin T fragments to assess heart muscle injury
Studies a blood test for troponin T fragments in people with suspected heart muscle injury.
Plain-language title generated from the registry record
Registry title: TROPOnin FRAGMentation in Myocardial Injury Study
Key facts
- Where
- Zurich, SwitzerlandSee the site
Where in Switzerland
- University Hospital ZurichZurich, SwitzerlandEnrolling by invitation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Turku
- Trial code
- NCT04465591
- Record updated
- 8 May 2026
- Original description
Troponin T (TnT) is a part of the troponin protein complex that principally exists in cardiac and skeletal muscle cells and is widely used as diagnostic biomarker for myocardial injury and, thus, myocardial infarction (MI). Elevated TnT levels can, however, be observed in the presence of other clinical conditions such as heart failure, sepsis and kidney failure and the contemporary high-sensitivity TnT test may yield false positive results when performing diagnostics for suspected MI in these patients.Read full original descriptionShow less
Troponin T Fragmentation in the Assessment of Myocardial Injury Study
Troponin T (TnT) is a part of the troponin protein complex that principally exists in cardiac and skeletal muscle cells and is widely used as diagnostic biomarker for myocardial injury and, thus, myocardial infarction (MI). Elevated TnT levels can, however, be observed in the presence of other clinical conditions such as heart failure, sepsis and kidney failure and the contemporary high-sensitivity TnT test may yield false positive results when performing diagnostics for suspected MI in these patients.
Recent data have demonstrated that in the presence of MI, TnT gradually undergoes fragmentation into smaller fragments. It has been suggested that in the presence of e.g. chronic kidney disease or physical exercise the released TnT is predominantly in the form of smaller fragments.
However, the clinical significance of TnT fragmentation is unknown and, thus, we sought to investigate the prevalence of fragmentation of TnT in different patient cohorts.
Inclusion: Troponin T fragmentation sample collected from a recruited patient.
Exclusion: Age <18.