Comparing Two Treatments to Prevent Bleeding from Swollen Veins in the Food Pipe
Compares carvedilol pills with banding procedure in adults with cirrhosis and high blood pressure.
Plain-language title generated from the registry record
Registry title: Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding
Key facts
- Where
- Tanta, EgyptSee the site
- Phase
- Phase 2/3
Where in Egypt
- Sherief Abd-ElsalamTanta, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sherief Abd-Elsalam
- Trial code
- NCT04499898
- Record updated
- 5 August 2020
- Original description
Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertensionRead full original descriptionShow less
Randomized Controlled Trial of Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding in Cirrhotic Patients With Arterial Hypertension
Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension
Inclusion: • Aged >18 years; Cirrhotic patients with arterial hypertension; Endoscopic evidence of medium/large-sized esophageal varices.
Exclusion: • History of variceal bleeding or previous primary prevention of varices; Portal vein thrombosis or previous porto-systemic shunts as TIPS; Patients on drugs affecting portal pressure (beta blockers, nitrates); Advanced cardiovascular disease including acute myocardial infarction, atrio-ventricular block, congestive heart failure, chronic peripheral ischemia, severe bradycardia; Patients with severe respiratory diseases (COPD, bronchial asthma); Uncontrolled diabetes mellitus; Renal impairment; Hepatocellular carcinoma; Allergy to carvedilol; Pregnancy or lactation.