Shorter Radiation Before Surgery for Soft Tissue Sarcoma
Tests shorter radiation courses before surgery in adults with soft tissue sarcoma.
Plain-language title generated from the registry record
Registry title: Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
Key facts
- Where
- Nashville, United StatesSee the site
- Phase
- Phase 2
Where in United States
- Vanderbilt-Ingram Cancer CenterNashville, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Vanderbilt-Ingram Cancer Center
- Trial code
- NCT04506008
- Record updated
- 28 March 2025
- Original description
The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.Read full original descriptionShow less
Prospective Observational Trial of Two Neoadjuvant Hypofractionated Radiotherapy Regimens Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.
Inclusion: Histologic diagnosis of a soft tissue sarcoma of extremity, pelvis, chest wall or trunk/abdominal wall (non-retroperitoneal location); ECOG performance status 0-2; Patient must be deemed able to comply with radiation treatment and surgery.
Exclusion: History of prior radiation to the same area to be irradiated; Active collagen vascular disease or patients genetically predisposed to increased radiation related side effects; Pregnancy.