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Taking people in SwitzerlandPhase 4

Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty

Key facts

Who runs it
Christian Candrian
Where
Lugano, SwitzerlandSee the site
Trial code
Status
Recruiting
Phase
Phase 4
People taking part
74 people, planned
Started
9 Sept 2020
Expected to end
31 Aug 2032
Type of study
Interventional, 2 groupsOne group gets no study treatment, for comparison.
Treatments tested
  • dexamethasone
Record updated
9 September 2026

Who can take part

Age
58 years to 85 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 17 criteriaShow less

Who can take part

  • Patients undergoing unilateral primary total anatomical or reverse shoulder arthroplasty (Total Shoulder Arthroplasty)
  • Patients with a BMI >18.5 and <35
  • Patients able to provide informed consent and follow all the study procedures as indicated by the protocol
  • Informed Consent as documented by signature

Who cannot take part

  • Contraindications to steroids
  • Active steroid or immunosuppressive therapy in the last 30 days before the operation
  • Presence of other clinically significant concomitant disease states (ASA IV)
  • Contraindications to Non-steroidal anti-inflammatory drugs
  • Known or suspected non-compliance, drug or alcohol abuse
  • Participation in another study with investigational drug within the 30 days preceding and during the present study
  • Previous enrolment into the current study
  • Uncontrolled diabetes mellitus
  • Chronic systemic diseases as immunodeficiency, autoimmune disease (Systemic Lupus Erythematosus), gout, rheumatic arthritis
  • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
  • Revision and post-traumatic TSA
  • Pregnant or breast-feeding women
  • Enrolment of the investigator, his/her family members, employees and other dependent persons

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 58 and 85 years old?

Where in Switzerland

  • Christian CandrianLugano, SwitzerlandContact: Christian Candrian, Prof.Dr.medTaking people

About the trial

What the trial wants to find out

The aim of the study is to evaluate if intravenous steroid supplementation can provide advantages over routine analgesia protocols in terms of post-operative symptoms (pain and nausea), length of hospital stay, shoulder range of motion, function and patient satisfaction

The 2 groups in the trial

  • arm ATreatment being tested

    • 9 mg of i.v. dexamethasone

    Treatment: dexamethasone

  • arm BNo study treatment, for comparison

    • no steroid supplementation

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Effect of Perioperative Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty for Osteoarthritis, in Terms of Post-operative Pain, Function, Nausea, Hospitalization Length, and Risk of Complications
Fit questions
Built from NCT04507412, who can take part
Record updated
9 September 2026