NCT04508088Recruiting
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
Source: ClinicalTrials.gov · Last updated 30 Oct 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 92 (estimated)
- First submitted
- 22 Jul 2020
- Start date
- 10 Sept 2020
- Primary completion date
- Dec 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Crohn's disease
- NCT number
- NCT04508088
What you commit to
- Study type: Observational
- Planned participants: 92
- From 10 Sept 2020 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants on certain medications within the prior 3 months that are known to affect skeletal metabolism
Other illness
- Participants with chronic disease known to affect skeletal metabolism
- Participants who have a history of: claustrophobia, internal body metal that is not compatible with MRI machine, or a known abnormality on or adjacent to the left knee
Other
- Participants who are pregnant
Who the study is looking for
- Crohn's Disease diagnosed within the past 3 months, or a healthy, matched control
Age in the registry: 13 years to 20 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Boston Children's Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.