NCT04537871Active, not recruiting
Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study
Cardiovascular Reserve Evaluation in Survivors of Transplantation (CREST)
Source: ClinicalTrials.gov · Last updated 14 Aug 2026
Brief summary (registry, in English)
This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 350 (actual)
- First submitted
- 27 Aug 2020
- Start date
- 18 Nov 2020
- Primary completion date
- 25 May 2027
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Acute lymphoblastic leukaemia, Hodgkin lymphoma, Myelodysplastic syndromes, Multiple myeloma, Acute myeloid leukemia
- NCT number
- NCT04537871
What you commit to
- Study type: Observational
- Participants enrolled: 350
- From 18 Nov 2020 to the primary completion date, 25 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Unstable angina or history of acute myocardial Infarction (\< 5 days of any planned study procedures)
- Uncontrolled arrhythmia causing symptoms
- Thrombosis of lower extremities
- Non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)
Lab values
- Anemia (hemoglobin \[Hgb\] \< 8 g/dL)
Other
- Unstable bone lesions per electronic medical record review and/or notification from patient's primary physician
- Recurrent syncope
- Acute myocarditis or pericarditis
- Symptomatic severe aortic stenosis
- Pulmonary embolus \< 3 month of study procedures
- Moderate or severe persistent asthma (National Asthma Education \& Prevention)
- Room air desaturation at rest =\< 85%
Who the study is looking for
- Age at HCT \>= 18 years
- Diagnosis of acute leukemia (myeloid, lymphoid), lymphoma (non-Hodgkin, Hodgkin), multiple myeloma or myelodysplastic syndromes
- Planning to undergo first autologous or allogeneic transplant
- Able to fluently read and write in English
- Able to understand and sign the study specific informed consent form (ICF)
- Physically able and willing to complete all study procedures
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.