Bilateral Knee Osteoarthritis: Intra-articular Injection of Filtered Autologous Adipose Tissue Versus Placebo

Who can take part

• bilateral degenerative chondropathy of the knees showing at least a grade 2-3 kellgren-lawrence classification (absence of severe osteoarthritis)
• An overall Pain subscale score of the Western Ontario and McMaster Universities Osteoarthritis Index between a value of 9 and 19
• Failure, intended as the persistence of symptomatology, after at least one conservative treatment cycle (pharmacological, physiotherapeutic or infiltrative treatment)
• Ability and informed consent of patients to actively participate in the rehabilitation protocol and clinical and radiological follow-up

Who cannot take part

• Patients who abuse alcoholic beverages, drugs or medicines
• Patients with a history of trauma or intra-articular infiltration of therapeutic substances in the 6 months prior to screening
• Patients who have had knee surgery in the 12 months prior to screening
• Diagnosis of leukaemia, known presence of metastatic malignant cells, ongoing or planned chemotherapy
• Diagnosis of rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis or arthritis resulting from another inflammatory disease; infection with human immunodeficiency virus (HIV), viral hepatitis; chondrocalcinosis
• Patients with uncontrolled diabetes mellitus
• Patients with uncontrolled thyroid metabolic disorders
• Patients incapable of understanding and wanting
• Patients with misalignment of the lower limbs above 10 degrees
• Body Mass Index > 40
• Pregnant or lactating state or intention to become pregnant during the period of participation in the study
• Patients with insufficient abdominal adipose tissue, assessed by the investigator