Unruptured Cerebral Aneurysm: Prediction of Evolution
Key facts
- Where
- Amiens, Angers, Besançon, Bordeaux, Brest, Caen, Clermont-Ferrand, Colmar, Dijon, Limoges, Marseille, Nancy, Nantes, Paris, Poitiers, Reims, Rennes, Rouen, Saint-Etienne, Strasbourg, Suresnes, Toulon, Toulouse, and Tours, FranceSee the 27 sites
Where in France
- Amiens University HospitalAmiens, FranceContact: Romain BOURCIER, MDTaking people
- Angers University HospitalAngers, FranceContact: Romain BOURCIER, MDTaking people
- CHU de BesançonBesançon, FranceContact: Alessandra BIONDITaking people
- Bordeaux University HospitalBordeaux, FranceContact: Romain BOURCIER, MDTaking people
- Brest University HospitalBrest, FranceContact: Romain BOURCIER, MDTaking people
- CHU de CAENCaen, FranceContact: Charlotte BARBIERTaking people
- CHU de Clermont-FerrandClermont-Ferrand, FranceContact: Emmanuel CHABERTTaking people
- Hôpitaux Civils de ColmarColmar, FranceContact: Pablo Ariel LEBEDINSKY, MDNot yet recruiting
- CHU DijonDijon, FranceContact: Pierre THOUANTTaking people
- Limoges university hospitalLimoges, FranceContact: Romain BOURCIER, MDTaking people
- Clairval's HospitalMarseille, FranceContact: Romain BOURCIER, MDTaking people
- Nancy University HospitalNancy, FranceContact: Romain BOURCIER, MDTaking people
- Nantes University HospitalNantes, FranceContact: Romain BOURCIER, MD (principal investigator)Taking people
- AP-HP La Pitié-Salpêtrière HospitalParis, FranceContact: Romain BOURCIER, MDTaking people
- AP-HP Le Kremlin Bicêtre HospitalParis, FranceContact: Romain BOURCIER, MDTaking people
- Rostchild Foundation HospitalParis, FranceContact: Romain BOURCIER, MDTaking people
- Ste Anne's HospitalParis, FranceContact: Romain BOURCIER, MDTaking people
- CHU de PoitiersPoitiers, FranceContact: Samy BOUCEBCITaking people
- Reims University HospitalReims, FranceContact: Romain BOURCIER, MDNo longer taking part
- Rennes University HospitalRennes, FranceContact: Romain BOURCIER, MDTaking people
- Rouen University HospitalRouen, FranceContact: Romain BOURCIER, MDTaking people
- Chu de Saint EtienneSaint-Etienne, FranceContact: Marina SACHETTaking people
- CHU de StrasbourgStrasbourg, FranceContact: Raoul POPTaking people
- Hopital FochSuresnes, FranceContact: Arturo CONSOLITaking people
- St Anne HIAToulon, FranceContact: Quentin HolayTaking people
- Toulouse University HospitalToulouse, FranceContact: Romain BOURCIER, MDTaking people
- Tours University HospitalTours, FranceContact: Romain BOURCIER, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Nantes University Hospital
- Trial code
- NCT04578808
- Record updated
- 25 September 2026
- Original description
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening. Besides, it will enable to exploit metadata and to explore new pathophysiological pathways of interest by crossing clinical, genetic, biological, and imaging information.Read full original descriptionShow less
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening. Besides, it will enable to exploit metadata and to explore new pathophysiological pathways of interest by crossing clinical, genetic, biological, and imaging information.
Inclusion: Subject carrying unruptured, asymptomatic and untreated typical IA of bifurcation, measured on conventional imaging (MRI, CTA or DSA) between 3 and 7 mm of larger diameter; Ability to be followed-up during 3 years decided in consensus multidisciplinary gathering; Age > 18 years old.
Exclusion: A failure to obtain informed consent; Contraindications for undergoing an MRI scan include : (heart pacemaker, a metallic foreign body (metal sliver) in their eye, or aneurysm clip in their brain, severe claustrophobia); A family history of polycystic kidney disease, Ehlers-Danlos syndrome, Marfan's syndrom, fibromuscular dysplasia, or Moya Moya disease; Contraindications for a gadolinium contrast medium injection (:eGFR below 30 mL/min/1.73 m2, Previous or pre-existing nephrogenic systemic fibrosis, Previous anaphylactic/anaphylactoid reaction to gadolinium containing contrast agent, Acutely deteriorating renal function, Pregnancy and breast-feeding); A mycotic, fusiform-shaped, or dissecting IA, an IA in relation with an arteriovenous malformation; Intra-cavernous UIA because the sinus cavernous that is fulfilled with venous blood precluded a reliable assessment of aneurysmal wall enhancement (AWE).