Registry study of patients with chronic chest pain and no blocked coronary arteries
Studies how microvascular disease is diagnosed in adults with chronic angina and clear arteries.
Key facts
- Who runs it
- Johannes Gutenberg University Mainz
- Where
- Mainz, GermanySee the site
- Trial code
- Registry title
- MICRO: a Registry Study in Patients With Microvascular Angina
- Status
- Recruiting
- People taking part
- 1,000 people, planned
- Started
- 10 Oct 2020
- Expected to end
- 10 Oct 2029
- Type of study
- Observational
- Treatments tested
- Assessment of microvascular function with intracoronary hemodilution
- Record updated
- 31 March 2022
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with long-lasting chest pain (angina) from the heart, and no blocked large heart arteries. Certain heart vessel measurements must be available.
- Age
- 18 to under 85 years
- Sex
- All sexes can join.
- Disease stage
- Chronic coronary syndrome (including angina-like symptoms) with angina class II-IV and signs of reversible ischemia on non-invasive testing.
- Earlier treatment
- Not stated, except that people with earlier bypass surgery on all major branches in the LAD and LCX areas, where IMR cannot be measured, cannot join.
- Biomarker or test result
- Measurements of IMR, RFR, FFR and CFR must be available.
Main reasons for not taking part
- Pregnancy or breastfeeding
- Left ventricular ejection fraction lower than 30%
- Decompensated congestive heart failure
- Kidney failure with creatinine >2mg/dl (177 µmol/L)
- Severe valvular heart disease
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Age ≥ 18 and <85 years
- Chronic coronary syndrome (including patients with anginal equivalents)
- Angina CCS class II-IV
- Evidence of reversible ischemia on non-invasive testing
- Availability of the following measurements:; Index of microvascular resistances (IMR),; Resting full-cycle ratio (RFR),; Fractional flow reserve (FFR),; Coronary flow reserve (CFR)
- Willingness to participate and ability to understand read and signed the informed consent document before the procedure
Who cannot take part
- Previous coronary artery bypass surgery (CABG) to all major branches in the LAD and left circumflex (LCX) territory, such that IMR cannot be measured
- Medical or psychological conditions that would jeopardize an adequate and orderly participation
- Decompensated congestive heart failure (CHF)
- Severe valvular heart disease
- Left ventricular ejection fraction lower than 30%
- Chronic or acute renal failure with creatinine >2mg/dl
- At least one of the following:
- Pregnancy and or lactation
- Patients with comorbidities limiting life expectancy to less than one year
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Where in Germany
- Universitätsmedizin MainzMainz, GermanyContact: Tommaso Gori, Dtt med, PhDTaking people
About the trial
What the trial wants to find out
The evidence above demonstrates that microvascular dysfunction is an important determinant of patient prognosis, which however remains poorly classified. Given the high burden of disease and the severity of the functional impairment in these patients, the lack of a clear definition for this disease has a potentially large clinical importance. It is important to better describe the phenotype of these patients, identify the predictors of prognosis, and determine the impact of diagnosis.
The group in the trial
- Patients undergoing coronary microvascular function assessment
Treatment: Assessment of microvascular function with intracoronary hemodilution
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Multicenter Registry on the Diagnosis of Patients With Chronic Angina and no Angiographic Coronary Artery Stenosis
- Plain-language title
- Registry study of patients with chronic chest pain and no blocked coronary arteriesGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT04612322, who can take part
- Record updated
- 31 March 2022