Liver transplant study for colorectal cancer that has spread to the liver
Studies liver transplantation in adults with colorectal cancer spread only to the liver.
Plain-language title generated from the registry record
Registry title: Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases
Key facts
- Where
- Valencia, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults whose colorectal cancer has spread only to the liver, cannot be removed by surgery and is controlled by chemotherapy. The study tests liver transplantation.
- Age
- 18 to 65 years
- Sex
- All sexes can join.
- Disease stage
- Colorectal adenocarcinoma already removed completely (R0 resection). Liver metastases that cannot be removed by surgery. No disease outside the liver. At least 1 year since the colorectal cancer was diagnosed, before joining the liver transplant waiting list.
- Earlier treatment
- Must have responded to 2 or fewer lines of chemotherapy (RECIST criteria). People with no neoadjuvant chemotherapy cannot join.
- Biomarker or test result
- BRAF mutated status excludes people. CEA must not be above 80 ng/ml when joining the waiting list.
Main reasons for not taking part
- Body mass index of 30 or more
- Positive HIV or HCV
- Pregnant at the time of joining
- BRAF mutation
- Liver metastases larger than 5 cm (2 in)
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT04616495, who can take part
Where in Spain
- Eva M MontalváValencia, SpainContact: Eva M Montalvá, PhDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Hospital Universitario La Fe
- Trial code
- NCT04616495
- Record updated
- 22 September 2023
- Original description
Multicentric prospective and observational study to assess the 5-year overall survival in a cohort of patients with unresectable liver-only colorectal metastases, well controlled by chemotherapy prior to liver transplantation.Read full original descriptionShow less
Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases
Multicentric prospective and observational study to assess the 5-year overall survival in a cohort of patients with unresectable liver-only colorectal metastases, well controlled by chemotherapy prior to liver transplantation.
Inclusion: ≥ 18 and ≤ years; Good performance status, ECOG 0 or 1; Resected adenocarcinoma in colon or rectum (R0 resection); Unresectable liver metastases; No extrahepatic disease; Normal blood tests; Response to ≤ 2 lines of chemotherapy (RECIST criteria); ≥ 1 year period since diagnosis of colorectal cancer to enrolment in liver transplant waiting list; Signed informed consent.
Exclusion: Deterioration of general condition (10% weight loss in the prior 6 months); Concomitant or prior extrahepatic metastases (histologically or radiologically proved), even if surgically resected; Palliative resection of primary colorectal adenocarcinoma; No neoadjuvant chemotherapy treatment; General contraindication to liver transplantation; Positive HIV or HCV; Other malignancy with disease free survival < 5 years; Body mass index ≥ 30; Pregnancy at the time of inclusion; BRAF mutated status; Liver metastases size > 5 cm (in the last imaging technique); CEA > 80 ng/ml (at time of enrolment in waiting list).