Brain Swelling Around Bleeding and Recovery After Brain Hemorrhage
Studies brain swelling after bleeding in the brain, using MRI scans and biomarkers, in adults.
Plain-language title generated from the registry record
Registry title: Influence of Cerebral Oedema in Intracerebral Haemorrhage
Key facts
- Where
- Lille, FranceSee the site
Where in France
- CHU de LilleLille, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Lille
- Trial code
- NCT04621357
- Record updated
- 22 April 2026
- Original description
In 2020, IntraCerebral Haemorraghe (ICH) remains the most devastating type of stroke. Besides stroke unit care, no specific treatment has been proven effective yet. Perihaematomal oedema (PHO) could be a promising therapeutic target. However, the mechanisms, the natural history as well as the clinical impact of this PHO remain unclear. The COPITCH study has been designed to answer these questionsRead full original descriptionShow less
Consequences of Oedema on the Prognosis of InTraCerebral Haemorrhage
In 2020, IntraCerebral Haemorraghe (ICH) remains the most devastating type of stroke. Besides stroke unit care, no specific treatment has been proven effective yet. Perihaematomal oedema (PHO) could be a promising therapeutic target. However, the mechanisms, the natural history as well as the clinical impact of this PHO remain unclear. The COPITCH study has been designed to answer these questions
Inclusion: With a spontaneous ICH, i.e. non traumatic; Admitted within 12 hours of stroke onset. For wake-up strokes, time of last seen well will be considered as stroke onset; Patient insured under the French social security; Consent form signed.
Exclusion: Contra-indication to MRI : claustrophobia, ocular metallic foreign bodies (accidental or other) or in a risk area (nervous or vascular system);irremovable implanted medical device (pacemaker, neurostimulator, cochlear implants and others);metallic heart valve (mainly old heart valves) or vascular clips previously implanted on cranial aneurysms; gadolinium allergy; "secondary" ICH: ICH resulting from intracranial vascular malformation, intracranial venous thrombosis, head trauma or tumour; haemorrhagic transformation within an infarct; Life expectancy of less than 1 year related to comorbidities (end stage cancer, end stage organ failure); Pregnancy or breastfeeding or Women of childbearing age without effective contraception (a pregnancy test will be done); Pure intraventricular haemorrhages; Pre-admission modified Rankin score of 4 or 5; Adults who are deprived of their liberty by judicial or administrative decision; Referral from other hospitals; No consent form.