Early Aspirin After Bleeding in the Brain Following Stroke Clot-Dissolving Treatment
Tests early aspirin in adults with a stroke and bleeding after clot-dissolving treatment.
Plain-language title generated from the registry record
Registry title: Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)
Key facts
- Where
- Hangzhou, ChinaSee the site
- Phase
- Phase 4
Where in China
- The Second Affiliated Hospital of Zhejiang UniversityHangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Trial code
- NCT04624295
- Record updated
- 15 June 2025
- Original description
Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic. Hemorrhagic Infarction was a part of the natural progression after acute ischemic stroke. Previous study have shown no significant relationship between hemorrhagic Infarction and poor outcome in acute ischemic stroke (AIS) patients. In this study, a randomized controlled trial will be conducted to explore the efficacy and safety of early antiplatelet therapy after hemorrhagic infarction in acute ischemic stroke treated with intravenous thrombolysis.Read full original descriptionShow less
Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis in China (HITs)：a Randomized Clinical Trial
Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic. Hemorrhagic Infarction was a part of the natural progression after acute ischemic stroke. Previous study have shown no significant relationship between hemorrhagic Infarction and poor outcome in acute ischemic stroke (AIS) patients. In this study, a randomized controlled trial will be conducted to explore the efficacy and safety of early antiplatelet therapy after hemorrhagic infarction in acute ischemic stroke treated with intravenous thrombolysis.
Inclusion: Acute ischemic patients receiving intravenous thrombolysis within 24 hours upon stroke onset; Be confirmed as Hemorrhagic Infarction at 24 to 36 hours after intravenous thrombolysis by computerized tomography; The patient or family member signed an informed consent.
Exclusion: Early use of anticoagulant drugs within 1 week after intravenous thrombolysis; Tirofiban was used after receiving endovascular treatment; Intraoperative stent placement after receiving endovascular treatment; Subarachnoid hemorrhage or ventricular hemorrhage; There are contraindications for aspirin use.