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NCT04624490RecruitingPhase 1

Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Source: ClinicalTrials.gov · Last updated 6 May 2026

Brief summary (registry, in English)

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Status (registry)
Recruiting
Phase (registry)
Phase 1
Study type
Interventional
Enrollment
260 (estimated)
First submitted
31 Oct 2020
Start date
2 Nov 2020
Primary completion date
26 Oct 2028
Lead sponsor
Mario Castro, MD, MPH
NCT number
NCT04624490

What you commit to

  • Study type: Interventional · Phase 1
  • Planned participants: 260
  • From 2 Nov 2020 to the primary completion date, 26 Oct 2028
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • MRI is contraindicated based on responses to MRI screening questionnaire
  • Subject is pregnant or lactating
  • Subject does not fit into 129Xe vest coil used for MRI
  • Subject cannot hold his/her breath for 15-16 seconds
  • Subject deemed unlikely to be able to comply with instructions during imaging
  • Oxygen saturation \<88% on room air or with supplemental oxygen
  • Cognitive deficits that preclude ability to provide consent
  • Institutionalization

Who the study is looking for

  • Healthy Volunteers:
  • Subject has no diagnosed pulmonary conditions
  • Ability to read and understand English or Spanish
    • Subjects with Lung Disease:
  • Subject has a diagnosis of pulmonary dysfunction made by a physician
  • No acute worsening of pulmonary function in the past 30 days
  • Ability to read and understand English or Spanish

Age in the registry: 3 years to - · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University of Kansas Medical Center
Coordinator of this site? Confirm its status		Kansas CityUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.