OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Key facts
- Who runs it
- St. Anne's University Hospital Brno, Czech Republic
- Where
- Brno, CzechiaSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 1 Nov 2020
- Expected to end
- 31 Jan 2029
- Type of study
- Observational, 2 groups
- Treatments tested
- aorto-bifemoral bypass surgery
- Record updated
- 27 April 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- patients scheduled for elective aorto-bifemoral bypass (AAA and Leriche syndrome patients)
Who cannot take part
- emergent surgery
- aorto-bifemoral bypass using deep vein graft
- re-operations
- known OSA with CPAP treatment
Where in Czechia
- St. Anne's University Hospital BrnoBrno, CzechiaContact: Ivan Cundrle, M.D., Ph.D.Taking people
About the trial
What the trial wants to find out
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure. Remote ischemic preconditioning (short periods of ischemia in anticipation of longer period of ischemia) may act protectively against ischemia.
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Studies of ischemic preconditioning in patients with AAA are conflicting. Obstructive sleep apnea (OSA) is a sleep disordered breathing syndrome which may have a protective effect against ischemia.
The investigators hypothesize that I/R injury will be less pronounced in patients who have OSA and that the extent of I/R injury will inversely correlate with OSA severity. Accordingly, the aim of this study is to compare postoperative complications and markers of I/R in patients undergoing elective AAA repair who do and do not have OSA.
The 2 groups in the trial
- Obstructive Sleep Apnea
Pacient with OSA (AHI≥5) undergoing aorto-bifemoral bypass
Treatment: aorto-bifemoral bypass surgery
- Without Obstructive Sleep Apnea
Patinets without OSA undergoing aorto-bifemoral bypass
Treatment: aorto-bifemoral bypass surgery
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Obstructive Sleep Apnea as a Remote Ischemic Preconditioning in Patients Scheduled for Aorto-bifemoral Bypass Surgery
- Record updated
- 27 April 2026