Multimodality Assessment of Ventricular Scar Arrhythmogenicity.
Key facts
- Who runs it
- St George's, University of London
- Where
- United Kingdom1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 18 people enrolled
- Started
- 1 Mar 2021
- Ended
- 2 Apr 2024
- Type of study
- Observational
- Treatments tested
- Generation of computational model from cardiac MRI.
- VT ablation
- Record updated
- 30 May 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
The registry criteria, word for word
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Who can take part
- Adult inpatients admitted to St George's Hospital London with sustained ventricular tachycardia or outpatients identified from the arrhythmia clinic with significant monomorphic ventricular tachycardia noted on cardiac monitoring who:
- Have sustained, monomorphic scar-dependent ventricular tachycardia
- Are symptomatic
- Failed, unable or unwilling to tolerate anti-arrhythmic medications
- Able to have a cardiac MRI
- Have a life expectancy > 1 year
- At least 40 days following a myocardial infarction
Who cannot take part
- Unable to have cardiac MRI
- Patients under the age of 18
- Patients who are unable to give informed consent
- Pregnant patients
- Prohibitive procedural risk
- Unable to tolerate the ablation procedure due to haemodynamic instability
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
We aim to improve our understanding of a life-threatening heart rhythm disorder known as ventricular tachycardia (VT). This is a disorder which originates from the lower chamber of the heart and frequently is associated with heart disease. We will use an MRI scan to generate a computer based model of the heart which can predict areas of the heart which are important in generating this rhythm disorder. We intend to assess how accurate this computer model is compared to traditional invasive assessment of the heart muscle. We also aim to assess the electrical characteristics of those areas which were predicted by the computer model in order to see why they were thought to be so important.
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All patients seen at St George's Hospital with VT will be eligible. As is routine for these patients, they will have an MRI scan of the heart. We will then use this scan to create a virtual reconstruction of the heart from which predictions of the critical areas of the heart which are generating the rhythm problem will be made. Then we will perform a VT ablation (studying the electrical properties and if necessary making a burn to treat the rhythm problem) - as per standard of care, however during the ablation we will spend extra time collecting information comparing the accuracy of the computer-generated model to the traditional invasive signals which guide ablation. We will study the electrical properties of those predicted areas to see what is special about them. The study will last up to three years.
The group in the trial
- Cases
Patients with scar-dependent ventricular tachycardia, requiring ablation. These patients will have satisfied the inclusion/exclusion criteria and be put forward for VT ablation. They will undergo the previously described study protocol, including generation of a computational model of the heart from their cardiac MRI and a VT ablation where we will study the points of interest generated from the MRI model in detail.
Treatment: Generation of computational model from cardiac MRI. and VT ablation
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Can MRI-based Computational Modelling of the Heart be Used to Predict Critical Substrate in Scar-dependent Ventricular Tachycardia Ablation?
- Publications
- Record updated
- 30 May 2025