CompletedNo phase
DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR)
Key facts
- Who runs it
- Ruijin Hospital
- Where
- China1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 64 people enrolled
- Started
- 14 May 2021
- Ended
- 7 Mar 2024
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- dexmedetomidine
- saline
- Record updated
- 15 January 2025
Who can take part
- Age
- 18 years to 65 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Age between 18- 65 years old
- Body mass index (BMI) between 18 and 35 kg/m\^2；
- Clinical diagnosis of chronic insomnia；
- Must be able to communicate with site personnel
Who cannot take part
- Current use of psychotropic drug
- Clinical diagnosis of mental disorders
- Clinical diagnosis of neurological diseases
- Pregnancy
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
It has been reported that dexmedetomidine, alpha-2 adrenoceptor agonist, can activate endogenous neural sleep pathways in the central nervous system. This randomised, double-blinded and controlled trial was designed to investigate whether dexmedetomidine can improve/treat chronic insomnia patients. Its effects on sleep quality and improvement, EEG and circadian rhythm, brain connectivity, cognition and biomarker changes are determined.
The 2 groups in the trial
- dexmedetomidineTreatment being tested
0.5μg/kg bolus injection in 10 minutes followed by 0.1µg/kg/hr pump infusion from 23:30 pm to 6:30 am
- salinePlacebo, for comparison
the same rate as dexmedetomidine
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effect of Dexmedetomidine on Patients With Chronic Insomnia and Its Influence on Circadian Rhythm:Randomized Clinical Trial, Double Blind
- Record updated
- 15 January 2025