Rheopheresis added to standard care for calciphylaxis in hemodialysis patients
Tests rheopheresis, a blood-filtering procedure, in adults on dialysis with calciphylaxis.
Plain-language title generated from the registry record
Registry title: Rheopheresis as Adjuvant Treatment of Calciphylaxis
Key facts
- Where
- Angers, Arras, Auxerre, Besançon, Béthune, Boulogne-sur-Mer, Bourdeaux, Brest, Caen, Grenoble, Laval, Le Mans, Lille, Limoges, Lyon, Marseille, Montpellier, Nantes, Niort, Reims, Toulouse, Valenciennes, Vandœuvre-lès-Nancy, Vannes, and Vichy, FranceSee the 29 sites
Where in France
- CHU d AngersAngers, FranceNot yet recruiting
- CHU d'ArrasArras, FranceTaking people
- CHU d'AuxerreAuxerre, FranceNot yet recruiting
- CHU de Besancon - Hopital Jean MinjozBesançon, FranceTaking people
- CH de BéthuneBéthune, FranceTaking people
- CH de Boulogne-sur-MerBoulogne-sur-Mer, FranceTaking people
- CHU de BordeauxBourdeaux, FranceNot yet recruiting
- CHRU de BrestBrest, FranceNot yet recruiting
- CHU de CAENCaen, FranceNot yet recruiting
- Hôpital Nord Michallon, CHU de GrenobleGrenoble, FranceTaking people
- Centre ECHO LavalLaval, FranceTaking people
- Centre ECHO Le MansLe Mans, FranceTaking people
- Hop Claude Huriez Chu LilleLille, FranceTaking people
- Hôpital Privé La LouviereLille, FranceTaking people
- CHR de LimogesLimoges, FranceTaking people
- Hopital Lyon SudLyon, FranceNot yet recruiting
- Hôpital Saint Joseph Saint LucLyon, FranceNot yet recruiting
- Hôpital de la Conception, AP-HMMarseille, FranceTaking people
- Institut Phocéen de Néphrologie - Clinique BouchardMarseille, FranceNot yet recruiting
- CHU de MontpellierMontpellier, FranceTaking people
- CHU de NantesNantes, FranceTaking people
- CH de NiortNiort, FranceNot yet recruiting
- CHU de ReimsReims, FranceTaking people
- CHU de ToulouseToulouse, FranceTaking people
- Clinique Saint ExupéryToulouse, FranceNot yet recruiting
- CH de ValenciennesValenciennes, FranceTaking people
- Chru de Nancy-BraboisVandœuvre-lès-Nancy, FranceNot yet recruiting
- Centre Hospitalier Bretagne AtlantiqueVannes, FranceNot yet recruiting
- CH de VichyVichy, FranceNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Lille
- Trial code
- NCT04654000
- Record updated
- 12 February 2026
- Original description
The investigators propose to set up a prospective randomized controlled trial to control the security and assess the efficacy of adjuvant treatment by rheopheresis in necrotizing-ulcered calciphylaxis in the hemodialysis population.Read full original descriptionShow less
Efficacy of Rheopheresis as Adjuvant Treatment of Calciphylaxis in Hemodialysis Patients : a Prospective Randomized Controled Single-blind Trial
The investigators propose to set up a prospective randomized controlled trial to control the security and assess the efficacy of adjuvant treatment by rheopheresis in necrotizing-ulcered calciphylaxis in the hemodialysis population.
Inclusion: Calciphylaxis with at least one ulcerated or necrotizing lesion; End stage renal disease requiring hemodialysis; Weight superior to 30kg; Subject affiliated to or beneficiary of a social security system; Subject having signed written informed consent; A patient with progressing calciphylaxis to ulcerate or necrosis despite conventional treatment may also be included.
Exclusion: Uncontrolled infection (persistence of fever despite appropriate antibiotic therapy); Severe cognitive or psychiatric disorders, patients unable to give an informed consent or unwilling to participate in the study; Albumin allergy; KARNOFSKY Performance Status Scale inferior to 30%; Life expectancy (independently of calciphylaxis) estimated < 6 months according to a referring physician expert in hemodialysis; Common variable immunodeficiency; Contra-indication to stop anti-vitamin K treatment; Pregnancy or breastfeeding and all the other categories of people with special protection according to the French Code de la Santé Publique (CSP): patients under legal supervision, patients hospitalized without contentment, patients admitted in social or sanitary structures for care and not research, and patients in emergency situations.