Comparing two heart rhythm procedures in people with heart failure and atrial fibrillation
Compares atrial fibrillation ablation with AV node ablation in adults with heart failure.
Plain-language title generated from the registry record
Registry title: Rate or Rhythm Control in CRT: the RHYTHMIC Study
Key facts
- Where
- London, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT04664686, who can take part
Where in United Kingdom
- Guys and St Thomas NHS Foundation TrustLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guy's and St Thomas' NHS Foundation Trust
- Trial code
- NCT04664686
- Record updated
- 26 January 2026
- Original description
70 patients with heart failure, AF and CRT with BiV<95% will be randomised to either AF ablation or AV node ablation. Evaluation at 6 months with echocardiography and clinical assessment.Read full original descriptionShow less
Rate or Rhythm Control in CRT: the RHYTHMIC Study
70 patients with heart failure, AF and CRT with BiV<95% will be randomised to either AF ablation or AV node ablation. Evaluation at 6 months with echocardiography and clinical assessment.
Inclusion: Ability to provide informed consent to participate and willing to comply with the clinical investigation plan and follow-up schedule; QRS duration >120ms on surface ECG, severe left ventricular systolic impairment (EF≤35%) and clinical symptoms of heart failure despite optimum medical therapy (NYHA class II-IV) at time of CRT implant or upgrade; Successful CRT implant or upgrade including atrial lead; Biventricular pacing percentage <95% secondary to atrial fibrillation at least 3 months post implant or upgrade; Clinically indicated for AV node ablation.
Exclusion: Severe peripheral vascular disease; Life expectancy <1 year; Presence of atrial or ventricular thrombus; Permanent atrial fibrillation; Mechanical aortic valve replacement; Female participants who are pregnant, lactating or planning pregnancy during the course of the study; Participation in other studies with active treatment / investigational arm.