Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion
Key facts
- Who runs it
- The University of Hong Kong
- Where
- Hong Kong1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Terminated
- People taking part
- 52 people enrolled
- Started
- 1 Dec 2020
- Ended
- 30 Oct 2024
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Seldinger chest drain insertion
- Record updated
- 28 March 2025
- Why it stopped
- difficult recruitment encountered during pandemic
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Patients who have cytologically/histologically proven pleural malignancy, or who have pleural effusion in the context of malignancy elsewhere
- The pleural effusion is at least moderate to massive and causes symptoms
- Ability to give informed written consent to the study
Who cannot take part
- Allergy to local anesthesia agents
- History of pleurodesis on the same side of malignant pleural effusion requiring drainage
- Bleeding tendency not readily correctable (platelet < 100 x 10\^9, INR ≥1.5 after transfusion)
- Age <18 years old
- Hydropneumothorax before drain insertion
- Moderate-heavy septations in the pleural effusion (defined as a collection with more than 4 septations visible at the maximally septated area)
- Clinical emergency that an urgent chest drain is required
- Blindness
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Malignant pleural effusion (MPE) is a very common medical condition, especially among patients with disseminated cancers. Chest drain insertion aims to drain the pleural fluid collection and relieve dyspnea. Small bore chest tubes are recommended as the first line therapy for draining pleural effusions. However, there is no clinical data available to inform on the size of drains for better drainage. This is a randomized study comparing the two common bores of small bore chest drains in Hong Kong, and assess for its clinical efficacy and complication risks.
The 2 groups in the trial
- Seldinger chest drain 14FOther group
Patients with seldinger chest drain 14F inserted
Treatment: Seldinger chest drain insertion
- Seldinger chest drain 8FExisting treatment, for comparison
Patients with seldinger chest drain 8F inserted
Treatment: Seldinger chest drain insertion
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Clinical Efficacy and Complications of Small-bore Versus Ultra-small Bore Chest Drain in Malignant Pleural Effusion: a Randomized Clinical Trial
- Record updated
- 28 March 2025