NCT04671433CompletedPhase 3
Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
Phase 3 Randomized, Controlled Study of AAV5-hRKp.RPGR for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
Source: ClinicalTrials.gov · Last updated 24 Sept 2026
Brief summary (registry, in English)
A clinical trial of AAV5-RPGR vector for participants with X-linked retinitis pigmentosa (XLRP)
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 105 (actual)
- First submitted
- 5 Nov 2020
- Start date
- 4 Dec 2020
- Primary completion date
- 30 Sept 2024
- Lead sponsor
- MeiraGTx Ocular UK Ltd
- Diseases
- Retinitis pigmentosa
- NCT number
- NCT04671433
- EudraCT number
- 2020-002873-88
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 105
- From 4 Dec 2020 to the primary completion date, 30 Sept 2024
- 28 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has had ocular surgery within 3 months prior to screening or is anticipated to require ocular surgery within 6 months after the study intervention administration
- Has undergone prior retinal surgery involving the macula, macular laser photocoagulation, external-beam radiation therapy, transpupillary thermotherapy, glaucoma filtration surgery or corneal surgery
Other
- Any investigational ocular treatment or any other ocular treatment that could confound the interpretation of the efficacy results or affect participant compliance with the visit schedule
Who the study is looking for
- Male or female
- 3 years of age or older
- Has XLRP confirmed by a retinal specialist and has a predicted disease-causing sequence variant in RPGR confirmed by an accredited laboratory
Age in the registry: 3 years to - · Sex: All · Does not accept healthy volunteers
Sites (28)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UZ Gent Coordinator of this site? Confirm its status | Ghent | Belgium | Unknown status |
| Hospital for Sick Children Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| University Hospital Basel, Eye Clinic/Institute of Molecular and Clinical Coordinator of this site? Confirm its status | Basel | Switzerland | Unknown status |
| Universite de Lausanne, Hopital ophtalmique Jules-Gonin Coordinator of this site? Confirm its status | Lausanne | Switzerland | Unknown status |
| Rigshospitalet Glostrup Coordinator of this site? Confirm its status | Glostrup Municipality | Denmark | Unknown status |
| Hosp Univ Fund Jimenez Diaz Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Centre Hospitalier National D'ophtalmologie Des Quinze Vingts Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| NHS Lothian Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Unknown status |
| Gartnavel General Hospital Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Unknown status |
| St James University Hospital Coordinator of this site? Confirm its status | Leeds | United Kingdom | Unknown status |
| Moorfields Eye Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Hadassah medical Center Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Azienda Ospedaliero-Universitaria Careggi Coordinator of this site? Confirm its status | Florence | Italy | Unknown status |
| Ospedale San Paolo Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Azienda Ospedaliera Univ.- Università Degli studi della Campania - Luigi Vanvitelli Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| IRCCS Fondazione G.B. Bietti per lo Studio e la Ricerca in Oftalmologia ONLUS Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| VUMC Amsterdam Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Unknown status |
| Radboudumc Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Unknown status |
| Univ of Michigan Medical Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Retina Consultants of Houston Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Massachusetts General Hospital - Center for Celiac Research and Treatment Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Duke Eye Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| VitreoRetinal Associates, PA Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| Shiley Eye Institute Jacobs Retina Center Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Childrens Hospital Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Stanford Health Care Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| University of Pittsburgh Medical Center (UPMC) Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.