Tests whether guided treatment helps chest pain without blocked coronary arteries
Tests a diagnostic procedure to guide treatment in adults with angina and no blocked arteries.
Plain-language title generated from the registry record
Registry title: iCorMicA - Stratified Medicine in Angina
Key facts
- Where
- Krakow, PolandSee the site
Where in Poland
- 5th Military HospitalKrakow, PolandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- NHS Greater Glasgow and Clyde
- Trial code
- NCT04674449
- Record updated
- 9 April 2026
- Original description
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.Read full original descriptionShow less
International Study of Coronary Microvascular Angina (iCorMicA): a Randomised, Controlled, Multicentre Trial and Registry
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.
Inclusion: Age ≥18 years; A clinical plan for invasive coronary angiography; Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires; Able to comply with study procedures; Able to provide informed consent.
Exclusion: A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure); History of coronary artery bypass surgery; Presence of obstructive disease evident in a main coronary artery (diameter >2.5 mm), i.e. a coronary stenosis >50% and/or a fractional flow reserve (FFR) ≤0.80*; Logistical reason*. *These patients will enter a follow-up registry.