Tests whether guided treatment helps chest pain without blocked coronary arteries
Tests a diagnostic procedure to guide treatment in adults with angina and no blocked arteries.
Plain-language title generated from the registry record
Registry title: iCorMicA - Stratified Medicine in Angina
Key facts
- Where
- Krakow, PolandSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with symptoms of angina who are already planned for an invasive coronary angiogram and have no blocked main heart artery.
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- Angina symptoms (typical or atypical) on the Rose and/or Seattle Angina questionnaires, with no blockage in a main coronary artery (diameter >2.5 mm).
- Earlier treatment
- No previous coronary artery bypass surgery.
Main reasons for not taking part
- Invasive angiography is planned mainly for a reason not linked to the coronary arteries (for example valve disease, heart failure)
- Previous coronary artery bypass surgery
- Blockage in a main coronary artery: stenosis >50% and/or fractional flow reserve (FFR) ≤0.80
- Logistical reason (these people enter a follow-up registry)
Read by machine on 12 November 2026.
Where in Poland
- 5th Military HospitalKrakow, PolandContact: Bartlomeij GuzikTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- NHS Greater Glasgow and Clyde
- Trial code
- NCT04674449
- Record updated
- 9 April 2026
- Original description
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.Read full original descriptionShow less
International Study of Coronary Microvascular Angina (iCorMicA): a Randomised, Controlled, Multicentre Trial and Registry
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.
Inclusion: Age ≥18 years; A clinical plan for invasive coronary angiography; Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires; Able to comply with study procedures; Able to provide informed consent.
Exclusion: A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure); History of coronary artery bypass surgery; Presence of obstructive disease evident in a main coronary artery (diameter >2.5 mm), i.e. a coronary stenosis >50% and/or a fractional flow reserve (FFR) ≤0.80*; Logistical reason*. *These patients will enter a follow-up registry.