Tests a serious game to help thinking and memory in multiple sclerosis
Tests a game-based training program for thinking and memory in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
Key facts
- Where
- Arras, Lens, Lille, Lomme, and Rouen, FranceSee the 6 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT04694534, who can take part
Where in France
- CH ArrasArras, FranceTaking people
- CH LensLens, FranceTaking people
- CHRULille, FranceTaking people
- Saint Vincent hospitalLille, FranceTaking people
- Saint-Philibert hospitalLomme, FranceTaking people
- Charles Nicolle HospitalRouen, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Lille Catholic University
- Trial code
- NCT04694534
- Record updated
- 4 September 2025
- Original description
The main goal of this study is to assess the effectiveness of a cognitive remediation program based on a "serious game" on the information processing speed evolution and the process of learning via episodic memory in multiple sclerosis patients.Read full original descriptionShow less
e-SEP Cognition: Effectiveness of a Remediation Program Via a "Serious Game" on the Cognitive Functions of Multiple Sclerosis Patients: Controlled, Randomized, Multicentric Trial
The main goal of this study is to assess the effectiveness of a cognitive remediation program based on a "serious game" on the information processing speed evolution and the process of learning via episodic memory in multiple sclerosis patients.
Inclusion: Relapsing-remitting or progressive multiple sclerosis people defined according to Mc Donald's criteria revised in 2005; Age between ≥ 18 and ≤ 65 years old; Cognitive complaint, with at least one deficient score at the initial neuropsychological examination (<5th percentile of the reference group), one of the scores of which concerns at least one BICAMS test; Have not had a definite relapse for at least 6 weeks; Be at least 4 weeks away from a corticosteroid bolus; Lack of neuroleptic treatment; Patient with an Internet connection; Signed informed consent.
Exclusion: Neurological or psychiatric comorbidity, other than MS and anxiodepressive syndrome; Patient with severe anxiodepressive syndrome (BDI> 27); Severe cognitive deficit defined by obtaining a deficit score in more than six cognitive processes at the initial neuropsychological assessment; Neuropsychological care; Inability to receive oral and written information; Inability to use the software (due in particular to motor and / or sensory difficulties),; Participation in an interventional study on cognitive functions; Patient under legal protection, guardianship or curatorship; Pregnant or breastfeeding women.