Drainage and hormone treatment for large ovarian endometrioma cysts
Studies drainage plus hormone medicine for large ovarian cysts in women of childbearing age.
Plain-language title generated from the registry record
Registry title: The Therapy of Large Endometrioma
Key facts
- Where
- Lisle-sur-Tarn, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT04704115, who can take part
Where in France
- Hop Jeanne de Flandre Chu LilleLisle-sur-Tarn, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Lille
- Trial code
- NCT04704115
- Record updated
- 23 December 2025
- Original description
Endometrioma's prevalence is between 23 and 55%. It causes pelvic pain, decrease fertility and ovarian reserve.Read full original descriptionShow less
Evaluate the Therapy of Large Ovarian Endometrioma
Endometrioma's prevalence is between 23 and 55%. It causes pelvic pain, decrease fertility and ovarian reserve.
Currently, there's no recommendation about large endometrioma's treatment and there's no information on the best treatment to limit recurrences, preserve fertility and ovarian reserve.
In Lille university hospital, simple laparoscopic drainage associated with hormonal therapy is practiced to reduce the risk of cystectomy.
This protocol will be evaluated with an observational and prospective study, including women of childbearing age having endometrioma measuring 6 cm or above.
The aim of this study is to assess if cyst drainage associated with GnRH agonist, could decrease endometrioma recurrences, deleterious effect on ovarian reserve and evaluate impact on anti-mullerian hormone
Inclusion: Endometrioma size ≥ 6cm determined by MRI or ultrasonography; Women with isolated endometrioma or other extraovarian endometriosis: peritoneal, infiltrating endometriotic lesions and adenomyosis; Cyst single or bilateral.
Exclusion: Cyst with radiographic or macroscopic in laparoscopy atypia; Pregnancy; Patient with contraindication to GnRH agonist (Enantone® 3,75 mg et Decapeptyl® 3 mg); Patient with contraindication to laparoscopy; Patient with contraindication to general anesthesia; Subject refusing to participate in the study.