Studies swallowing and voice-box function in people with neurodegenerative diseases

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a neurodegenerative disease, such as multiple system atrophy, progressive supranuclear palsy, Parkinson's disease or motor neurone disease. They must have had a swallowing and throat check with a camera (FEES) using a set task protocol.

Age

18 years or older

Sex

All sexes can join.

Disease stage

Probable or possible multiple system atrophy, probable or possible progressive supranuclear palsy, Parkinson's disease (Hoehn and Yahr stage I-V), motor neurone disease, or another neurodegenerative disease.

Main reasons for not taking part

• People who do not sign the consent form cannot join.
• Healthy volunteers cannot join.

The registry criteria, word for word

What the trial wants to find out

This is a non-interventional observational study designed to systematically record the results of routine laryngeal examinations and specific characteristics of dysphagia in patients with neurodegenerative disorders. The results of a fiberoptic / flexible endoscopic evaluation of swallowing (FEES) while performing a structured task protocol will be recorded. If available, laryngeal electromyography (EMG) results will also be recorded. In addition to the examination results, demographic and disease-specific data are collected, and two questionnaires, the Swallowing Disturbance Questionnaire for Parkinson's Disease (SDQ-PD) and the swallowing specific Quality Of Life Questionnaire (SWALQOL), are administered.

The 5 groups in the trial

• Multiple System Atrophy

  Patients diagnosed will probable or possible MSA according to the 2nd criteria for the diagnosis of MSA (Gilman 2008) that received laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).

• progressive supranuclear palsy

  Patients diagnosed will probable or possible Progressive Supranuclear Palsy or (PSP) related 4repeat tauopathies according to the Movement Disorders Society diagnostic criteria (Höglinger 2017) that received laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).

• Parkinson Disease

  Patients diagnosed will Parkinson's disease according to the Movement Disorders Society diagnostic criteria (Postuma 2015) that received laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).

• Motor Neuron Disease

  Patients diagnosed with Motor Neuron Disease that received laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).

• Neurodegenerative Diseases

  Patients diagnosed with a neurodegenerative disease not specified above that received laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).