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Taking people in CanadaPhase 3

Tests 18F-DOPA PET imaging in people with several conditions

Studies how 18F-DOPA PET scans are performed in children and adults with various conditions.

Key facts

Who runs it
University of Alberta
Where
Edmonton, CanadaSee the site
Trial code
Registry title
18F-DOPA II - PET Imaging Optimization
Status
Recruiting
Phase
Phase 3
People taking part
800 people, planned
Started
20 Jan 2021
Expected to end
Dec 2027
Type of study
Interventional
Treatments tested
  • 18F-DOPA
  • Furosemide Injection
Record updated
9 February 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for children and adults who need an 18F-DOPA PET/CT scan: congenital hyperinsulinism, neuroblastoma, neuroendocrine tumor, suspected Parkinson's disease or Lewy body dementia, or brain tumor.

Age
Children under 18 years old and adults 18 or older, depending on the condition.
Sex
All sexes can join.
Disease stage
Known or suspected neuroendocrine tumor; clinical suspicion of Parkinson's disease or Lewy body dementia; congenital hyperinsulinism, neuroblastoma or brain tumor.
Earlier treatment
A previous gallbladder removal (cholecystectomy) rules out only the dynamic abdomen sub-study.

Main reasons for not taking part

  • Cannot give consent
  • Weight over 225 kg (496 lb)
  • Adults who cannot lie flat for 20-30 minutes
  • Children under 13 who cannot lie flat for 20-30 minutes and cannot be sedated
  • Pregnancy

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Pediatric patients (less than 18 years old) with congenital hyperinsulinism
  • Pediatric patients (less than 18 years old) with neuroblastoma
  • Pediatric (less than 18 years old) or Adult patients (18 or older) with known or clinically suspected neuroendocrine tumor
  • Adult patients (18 or older) with a clinical suspicion of Parkinson's disease or Lewy body dementia
  • Pediatric (less than 18 years old) or Adult patients (18 or older) with brain tumors

Who cannot take part

  • History of previous cholecystectomy (excluded from dynamic abdomen sub-study only)
  • Young pediatric patients (less than 13 years old) who are unable to lie flat for 20-30 minutes and for whom clinical sedation is contraindicated (as determined by a pediatric anaesthesiologist)
  • Unable to obtain consent
  • Weight >225 kg (weight limitation of PET/CT scanner)
  • Adult patients unable to lie flat for 20-30 minutes to complete the PET-CT session
  • Lack of intravenous access
  • Pregnancy

Where in Canada

  • WC Mackenzie Health Science Centre / University of Alberta HospitalEdmonton, CanadaContact: Jonathan Abele, MDTaking people

About the trial

What the trial wants to find out

A single centre non-randomized, non-blinded phase III prospective cohort study of 18F-DOPA PET/CT imaging in specific patient populations:

Read full original descriptionShow less

1. Pediatric patients (less than 18 years old) with congenital hyperinsulinism. 2. Pediatric patients (less than 18 years old) with neuroblastoma. 3. Pediatric (less than 18 years old) or Adult patients (18 or older) with known or clinically suspected neuroendocrine tumor. 4. Adult patients (18 or older) with a clinical suspicion of Parkinson's disease or Lewy body dementia. 5. Pediatric (less than 18 years old) or Adult patients (18 or older) with brain tumors.

Image optimization (the primary study objective) and gallbladder activity pattern (the secondary objective) will be evaluated.

The group in the trial

  • 18F-DOPA injectionTreatment being tested

    All enrolled participants will receive an intravenous injection of the investigational 18F-DOPA radiopharmaceutical

    Treatment: 18F-DOPA and Furosemide Injection

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
18F-DOPA II - PET Imaging Optimization
Plain-language title
Tests 18F-DOPA PET imaging in people with several conditionsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
9 February 2026