Early access
Sign in
TerminatedPhase 3

Long-term Safety Study of Adjunctive Troriluzole in Subjects With Obsessive Compulsive Disorder

Key facts

Who runs it
Biohaven Pharmaceuticals, Inc.
Where
Allentown, Anaheim, Ann Arbor, Apopka, Atlanta, Austin, Bangor, Baytown, Beavercreek, Bellevue, Bellflower, Berlin, Beverly Hills, Boca Raton, Boise, Boston, Brooklyn, Bryan, Canton, Cedarhurst, Chandler, Cherry Hill, Chicago, Cincinnati, Colton, Coral Gables, Coral Springs, Costa Mesa, Culver City, Dallas, Dayton, Decatur, Denver, DeSoto, Elgin, Encino, Fayetteville, Flowood, Fort Myers, Fort Worth, Gainesville, Gaithersburg, Glendale, Great Neck, Hartford, Hialeah, Houston, Imperial, Jacksonville, Lakeland, Lancaster, Las Vegas, Lauderhill, Lemon Grove, Libertyville, Little Rock, Long Beach, Los Alamitos, Los Angeles, Lutz, Maitland, Media, Mesquite, Methuen, Miami, Miami Gardens, Miami Springs, Missoula, Missouri City, Mount Kisco, Mt. Pleasant, Naperville, Naples, New Haven, New London, New Port Richey, New York, Newport Beach, North Bay Village, North Miami, North Miami Beach, Norwich, O'Fallon, Oakland, Oceanside, Oklahoma City, Orange, Orange City, Orlando, Palmetto Bay, Pembroke Pines, Philadelphia, Phoenix, Pikesville, Pinellas Park, Plano, Prairie Village, Redlands, Riverside, Rochester, San Antonio, San Diego, San Jose, Santa Ana, Savannah, Sherman Oaks, Snellville, Springfield, St Louis, Stanford, Staten Island, Sweetwater, Tampa, Toms River, Torrance, Towson, Tulsa, Upland, Watertown, Wichita Falls, Winter Park, and Woodstock, United StatesSee the 147 sitesAlso in 5 other countries, 28 sites
Status
Terminated
Phase
Phase 3
People taking part
772 people enrolled
Started
30 Mar 2021
Ended
13 Feb 2026
Type of study
Interventional
Treatments tested
  • Troriluzole (BHV-4157)
Record updated
25 February 2026
Why it stopped
Sponsor Decision

Who can take part

Age
18 years to 65 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

  • Eligible subjects are those subjects who complete study BHV4157-302 or BHV4157-303 and for whom the investigator believes open-label treatment offers an acceptable risk-benefit profile
  • Determined by the investigator to be medically stable at the week 10 visit of BHV4157-302 or BHV4157-303, as assessed by medical history, physical examination, laboratory test results, and electrocardiogram testing
  • It is required that all women of child-bearing potential (WOCBP) who are sexually active agree to use two methods of contraception for the duration of the study

Who cannot take part

  • Patients who may have received a non-biological investigational agent in any clinical trial within 30 days or a biological agent within 90 days prior to entry, other than what was received in BHV4157-302 or BHV4157-303
  • Subjects who did not successfully complete 10 weeks of treatment in the BHV4157-302 or BHV4157-303 study
  • Acute suicidality or suicide attempt or self injurious behavior in the last 12 months

Where in United States

Also in 5 other countries, 28 sites

  • Lehigh Center for Clinical ResearchAllentown, United States
  • Advanced Research Center, Inc.Anaheim, United States
  • Michigan Clinical Research Institute PCAnn Arbor, United States
  • Topaz Clinical ResearchApopka, United States
  • NeuroTrials Research IncAtlanta, United States
  • BioBehavioral Research of AustinAustin, United States
  • Northern Light Acadia HospitalBangor, United States
  • Inquest Clinical ResearchBaytown, United States
  • Clinical Inquest Center LtdBeavercreek, United States
  • Northwest Clinical Research CenterBellevue, United States
  • CITrials (Clinical Innovations)Bellflower, United States
  • Hassman Research InstituteBerlin, United States
  • Southern California Research, LLCBeverly Hills, United States
  • Boca Raton Medical InstituteBoca Raton, United States
  • Northwest Clinical TrialsBoise, United States
  • Boston Clinical TrialsBoston, United States
  • Massachusetts General HospitalBoston, United States
  • Integrative Clinical Trials, LLCBrooklyn, United States
  • SPRI Clinical Trials, LLCBrooklyn, United States
  • DiscoveResearch, Inc. (DRI)Bryan, United States
  • NeuroScience Research Center LLCCanton, United States
  • Neurobehavioral Research, Inc.Cedarhurst, United States
  • Metropolitan Neuro Behavioral InstituteChandler, United States
  • Center For Emotional FitnessCherry Hill, United States
  • University of Chicago Department of Psychiatry & Behavioral NeuroscienceChicago, United States
  • Uptown Research InstituteChicago, United States
  • CTI Clinical Research CenterCincinnati, United States
  • Axiom Research, LLCColton, United States
  • Advanced Clinical Research NetworkCoral Gables, United States
  • CNS Research of Coral SpringsCoral Springs, United States
  • Global Clinical TrialsCosta Mesa, United States
  • ProScience Research GroupCulver City, United States
  • FutureSearch Trials of Dallas, LPDallas, United States
  • Relaro Medical TrialsDallas, United States
  • Midwest Clinical Research CenterDayton, United States
  • iResearch Atlanta, LLCDecatur, United States
  • Mountain View Clinical ResearchDenver, United States
  • InSite Clinical ResearchDeSoto, United States
  • Revive Research InstituteElgin, United States
  • WR-PRI, LLC (Encino)Encino, United States
  • Carolina Institute For Clinical ResearchFayetteville, United States
  • Precise Research CentersFlowood, United States
  • Gulfcoast Clinical Research CenterFort Myers, United States
  • North Texas Clinical TrialsFort Worth, United States
  • University of Florida Department of PsychiatryGainesville, United States
  • CBH HealthGaithersburg, United States
  • Behavioral Research Specialists, LLCGlendale, United States
  • Bio Behavioral InstituteGreat Neck, United States
  • Institute of Living Hartford HospitalHartford, United States
  • Galiz ResearchHialeah, United States
  • Health Care Family Rehab & ResearchHialeah, United States
  • Qway Research, LLCHialeah, United States
  • Research in Miami IncHialeah, United States
  • Baylor College of MedicineHouston, United States
  • Clinical Trial NetworkHouston, United States
  • Texas Center for Drug Development, Inc.Houston, United States
  • Sun Valley Research Center, Inc.Imperial, United States
  • Clinical NeuroScience Solutions IncJacksonville, United States
  • Accel Research Sites (formerly Meridien Research)Lakeland, United States
  • Om Research LLCLancaster, United States
  • Altea ResearchLas Vegas, United States
  • Innovative Clinical Research, Inc.Lauderhill, United States
  • Synergy Research San DiegoLemon Grove, United States
  • Capstone Clinical ResearchLibertyville, United States
  • Atria Clinical ResearchLittle Rock, United States
  • Alliance for ResearchLong Beach, United States
  • Pharmacology Research InstituteLos Alamitos, United States
  • CalNeuro Research GroupLos Angeles, United States
  • Clarity Clinical ResearchLos Angeles, United States
  • Pharmaceutical Research Center, Inc.Lutz, United States
  • ClinCloud, LLCMaitland, United States
  • Meridien ResearchMaitland, United States
  • Suburban Research AssociatesMedia, United States
  • SMS Clinical ResearchMesquite, United States
  • ActivMed Practices and ResearchMethuen, United States
  • Central Miami Medical InstituteMiami, United States
  • Clintex ResearchMiami, United States
  • Ezy Medical Research Co.Miami, United States
  • FIRCMiami, United States
  • Florida Research Center, Inc.Miami, United States
  • Med-Care ResearchMiami, United States
  • Miami Dade Medical Research InstituteMiami, United States
  • Sanchez Clinical Research ,IncMiami, United States
  • Pro-Care Research CenterMiami Gardens, United States
  • South Florida Research Phase I-IV INCMiami Springs, United States
  • Boeson ResearchMissoula, United States
  • Mt.Olympus Medical Research LLCMissouri City, United States
  • Bioscience Research LLCMount Kisco, United States
  • Coastal Carolina Research CenterMt. Pleasant, United States
  • AMR-Baber Research IncNaperville, United States
  • Advanced Research for Health ImprovementNaples, United States
  • Yale UniversityNew Haven, United States
  • Coastal Connecticut Research, LLCNew London, United States
  • Bayside Clinical Research, LLCNew Port Richey, United States
  • Hapworth ResearchNew York, United States
  • Manhattan Behavioral Medicine PLLCNew York, United States
  • New York State Psychiatric InstituteNew York, United States
  • Pharmacology Research Institute (WR-PRI, LLC)Newport Beach, United States
  • Bravo Health Care CenterNorth Bay Village, United States
  • Behavioral Clinical ResearchNorth Miami, United States
  • Harmony Clinical ResearchNorth Miami Beach, United States
  • Comprehensive Psychiatric CareNorwich, United States
  • Psychiatric Care and Research CenterO'Fallon, United States
  • Pacific Research PartnersOakland, United States
  • Excell Research, Inc.Oceanside, United States
  • North County Clinical ResearchOceanside, United States
  • IPS ResearchOklahoma City, United States
  • NRC Research InstituteOrange, United States
  • Medical Research Group of Central FloridaOrange City, United States
  • APG Research, LLCOrlando, United States
  • Combined Research Orlando Phase I-IVOrlando, United States
  • Omega Research ConsultantsOrlando, United States
  • IMIC, Inc.Palmetto Bay, United States
  • MedBio TrialsPembroke Pines, United States
  • University of PennsylvaniaPhiladelphia, United States
  • Alea ResearchPhoenix, United States
  • NoeisisPharma, LLCPhoenix, United States
  • Pharmasite Research, IncPikesville, United States
  • DMI ResearchPinellas Park, United States
  • AIM TrialsPlano, United States
  • Collective Medical ResearchPrairie Village, United States
  • Anderson Clinical ResearchRedlands, United States
  • CI TrialsRiverside, United States
  • Finger Lakes Clinical ResearchRochester, United States
  • Clinical Trials of Texas IncSan Antonio, United States
  • ACRC StudiesSan Diego, United States
  • Lumos Clinical Research Center LLCSan Jose, United States
  • National Research InstituteSanta Ana, United States
  • iResearch SavannahSavannah, United States
  • California Neuroscience Research Medical Group, Inc.Sherman Oaks, United States
  • Renew Health Clinical Research LLCSnellville, United States
  • Sisu at RMGSpringfield, United States
  • PsychCare Consultants ResearchSt Louis, United States
  • Stanford UniversityStanford, United States
  • Richmond Behavioral AssociatesStaten Island, United States
  • LENUS Research & Medical Group, LLCSweetwater, United States
  • Olympian Clinical ResearchTampa, United States
  • Stedman Clinical TrialsTampa, United States
  • Bio Behavioral HealthToms River, United States
  • Collaborative Neuroscience ResearchTorrance, United States
  • Continental Clinical Solutions, LLCTowson, United States
  • Central States Research, LLCTulsa, United States
  • Pacific Clinical Research Medical GroupUpland, United States
  • Adams ClinicalWatertown, United States
  • Grayline Research CenterWichita Falls, United States
  • Conquest Research, LLCWinter Park, United States
  • Woodstock Research CenterWoodstock, United States

About the trial

What the trial wants to find out

The purpose of the study is to evaluate the long term safety and tolerability of troriluzole as adjunctive therapy in subjects with obsessive compulsive disorder (OCD).

The group in the trial

  • Troriluzole (BHV-4157)Treatment being tested

    200 mg daily first 2 weeks, 280 daily following first 2 weeks

Data and sources

Registry record
Listed on ClinicalTrials.gov and on the EU's official list of trials (CTIS).
Official title
A Multicenter, Long-Term Open-Label Safety Study of Adjunctive Troriluzole in Subjects With Obsessive Compulsive Disorder
Record updated
25 February 2026