CT Heart Imaging Tests for People With Stable Chest Pain
Tests combined heart CT scans to guide treatment in people with chest pain.
Plain-language title generated from the registry record
Registry title: CT Stress Myocardial Perfusion, Fractional Flow Reserve and Angiography in Patients With Stable Chest Pain Syndromes
Key facts
- Where
- Copenhagen, DenmarkSee the site
Where in Denmark
- Department of Cardiology and Radiology, Rigshospitalet, The Heart Center, Capital Region of Copenhagen, University of CopenhagenCopenhagen, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT04709900
- Record updated
- 5 November 2026
- Original description
The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve (FFR-CT) and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes) is to determine the ability of combined anatomical and functional cardiac CT imaging to improve morbidity and mortality in patients with suspected or known ischemic heart disease.Read full original descriptionShow less
DYnamic CT Stress Myocardial perfusioN, CT Fractional Flow Reserve and Coronary CT Angiography for Optimized treatMent Strategy In Patients With sTable Chest Pain syndromEs
The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve (FFR-CT) and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes) is to determine the ability of combined anatomical and functional cardiac CT imaging to improve morbidity and mortality in patients with suspected or known ischemic heart disease.
Inclusion: Chest pain in patients with clinically suspected or confirmed ischemic heart disease; Clinical indication for non-acute coronary evaluation; Status of coronary revascularization; With previous coronary revascularization - all patients; Without previous coronary revascularization; Age≥65 years - all patients with chest pain; Age>50 - <65 years - typical angina pectoris and at least one cardiovascular risk factor and/or previous myocardial infarction; Typical angina requiring all 3 criteria present: a) constrictive discomfort in the front of the chest or in the neck, jaw, shoulder or arm, b) precipitated by physical exertion c) relieved by rest or nitrates within 5 min; Cardiovascular risk factors: hypertension, diabetes, hypercholesterolemia, current smoking, family history of ischemic heart disease, previous stroke, peripheral artery disease.
Exclusion: Persistent chest pain and signs of ongoing acute myocardial ischemia requiring acute coronary intervention; Hospitalization and discharge with the confirmed diagnosis acute coronary syndrome (STEMI or NSTEMI) within the last 6 months; Severe valvular heart disease as primary diagnosis and/or in potential need of percutaneous or surgical valve treatment; Known renal impairment (estimated Glomerular Filtration Rate below <30 ml/min); Known x-ray contrast allergy; Known severe heart failure (LVEF less than 35%); Language, cultural or mental factors preventing the patient from understanding the informed consent form; Known atrial fibrillation; Known intolerance to adenosine infusion.