Concentration Impact Nicotine Salt

Who can take part

• Adult (≥ 18 years old) smokers (at least 5 TC per day for at least 12 months)
• Motivated to quit smoking as evidenced by signing the informed consent form at trial enrolment specifying that a target quit date will be set
• Exhaled CO ≥ 10 ppm or saliva cotinine of > 30 ng/ml (in case of borderline CO measurement of 6-10 ppm) at screening
• Willing to participate in the trial even if allocated to the control group
• Ability to communicate well with the investigator and to understand and comply with the requirements of the study
• Signed informed consent form

Who cannot take part

• Use of NRT, varenicline, or bupropion in the month prior to the screening visit
• Participation in an interventional trial within 30 days prior to the screening visit
• Known hypersensitivity/allergy to a content of the e-liquid
• Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol
• Pregnancy or breast feeding
• Intention to become pregnant during the course of the study
• Current regular use of EC or tobacco heating systems
• People who smoke tobacco combined with marijuana and do not currently want to quit marijuana use
• Legal incapacity or limited legal capacity at screening