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Taking people in United StatesPhase 1/2

Testing bone marrow and blood in children with relapsed or hard-to-treat leukemia

Examines bone marrow and blood samples from young people with leukemia that returned.

Key facts

Who runs it
PedAL BCU, LLC
Where
Akron, Albany, Albuquerque, Allentown, Anchorage, Ann Arbor, Asheville, Atlanta, Aurora, Austin, Baltimore, Bangor, Bethesda, Birmingham, Boise, Boston, Brooklyn, Chapel Hill, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Corpus Christi, Dallas, Danville, Dayton, Denver, Des Moines, Detroit, Downey, Durham, East Lansing, El Paso, Falls Church, Fargo, Fort Lauderdale, Fort Myers, Fort Worth, Gainesville, Grand Rapids, Greenville, Hackensack, Hartford, Hershey, Hollywood, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Loma Linda, Long Beach, Los Angeles, Louisville, Lubbock, Madera, Madison, Marshfield, Maywood, Memphis, Mesa, Miami, Mineola, Minneapolis, Mobile, Morgantown, Morristown, Nashville, Neptune City, New Brunswick, New Haven, New Hyde Park, New Orleans, New York, Norfolk, Oak Lawn, Oakland, Oklahoma City, Omaha, Orange, Orlando, Palo Alto, Park Ridge, Paterson, Pensacola, Peoria, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Richmond, Roanoke, Rochester, Royal Oak, Salt Lake City, San Antonio, San Diego, San Francisco, Savannah, Scarborough, Seattle, Sioux Falls, Spokane, Springfield, St Louis, St. Petersburg, Stony Brook, Syracuse, Tacoma, Tampa, The Bronx, Toledo, Tucson, Valhalla, Washington D.C., West Palm Beach, Wilmington, Winfield, and Winston-Salem, United StatesSee the 164 sitesAlso in 4 other countries, 20 sites
Trial code
Registry title
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
Status
Recruiting
Phase
Phase 1/2
People taking part
960 people, planned
Started
18 Apr 2022
Expected to end
31 Dec 2030
Type of study
Interventional
Treatments tested
  • Biospecimen Collection
Record updated
25 August 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for children, teens and young adults under 22 whose leukemia or related blood disease has come back or did not respond to treatment. Blood and bone marrow are tested to find a fitting study.

Age
Under 22 years
Sex
All sexes can join
Disease stage
Known or suspected relapsed or hard-to-treat (refractory) acute myeloid leukemia (AML), myeloid leukemia of Down syndrome, mixed phenotype acute leukemia (MPAL), or juvenile myelomonocytic leukemia (JMML). Also relapsed B-ALL or T-ALL as defined in the protocol, and new or relapsed treatment-related AML, myelodysplastic syndrome (MDS) or treatment-related MDS.
Biomarker or test result
For B-ALL: a second or later relapse in the bone marrow, not counting KMT2Ar. Or any first or later B-ALL bone marrow relapse involving KMT2Ar. For T-ALL: any first or later bone marrow relapse, with or without KMT2Ar.

The registry criteria, word for word

Show all 4 criteriaShow less

Who can take part

  • Patients must be less than 22 years of age at the time of study enrollment
  • Patient must have one of the following at the time of study enrollment:; Patient has known or suspected relapsed/refractory (including primary refractory) AML as defined in protocol; This includes isolated myeloid sarcoma; Patient has known or suspected relapsed/refractory (including primary refractory) myeloid leukemia of Down syndrome (ML-DS); Patient has known or suspected relapsed ALL as defined in protocol that meets one of the following criteria:; Second or greater B-ALL medullary relapse, excluding KMT2Ar; Any first or greater B-ALL medullary relapse involving KMT2Ar; Any first or greater T-ALL medullary relapse with or without KMT2Ar; Patient has known or suspected relapsed/refractory (including primary refractory) mixed phenotype acute leukemia (MPAL) as defined in protocol; Patient has known or suspected de novo or relapsed/refractory (including primary refractory) treatment-related AML (t-AML); Patient has known or suspected de novo or relapsed/refractory (including primary refractory) myelodysplastic syndrome (MDS) or treatment-related myelodysplastic syndrome (t-MDS); Note: Relapsed/refractory disease includes stable disease, progressive disease, and disease relapse; Patient has known or suspected de novo or relapsed/refractory (including primary refractory) juvenile myelomonocytic leukemia (JMML); Note: Relapsed/refractory disease includes stable disease, progressive disease, and disease relapse
  • All patients and/or their parents or legal guardians must sign a written informed consent
  • All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Where in United States

Also in 4 other countries, 20 sites

  • Children's Hospital Medical Center of AkronAkron, United StatesContact: Erin Wright (principal investigator)Taking people
  • Albany Medical CenterAlbany, United StatesContact: Lauren R. Weintraub (principal investigator)Taking people
  • University of New Mexico Cancer CenterAlbuquerque, United StatesContact: Jessica M. Valdez (principal investigator)Taking people
  • Lehigh Valley Hospital-Cedar CrestAllentown, United StatesContact: Jacob A. Troutman (principal investigator)Taking people
  • Providence Alaska Medical CenterAnchorage, United StatesContact: Brenda J. Wittman (principal investigator)Taking people
  • C S Mott Children's HospitalAnn Arbor, United StatesContact: Joshua W. Goldman (principal investigator)Taking people
  • Mission HospitalAsheville, United StatesContact: Douglas J. Scothorn (principal investigator)Taking people
  • Children's Healthcare of Atlanta - Arthur M Blank HospitalAtlanta, United StatesContact: Himalee S. Sabnis (principal investigator)Taking people
  • Children's Hospital ColoradoAurora, United StatesContact: Kelly E. Faulk (principal investigator)Taking people
  • Dell Children's Medical Center of Central TexasAustin, United StatesContact: Shannon M. Cohn (principal investigator)Taking people
  • Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesContact: Stacy L. Cooper (principal investigator)Taking people
  • Sinai Hospital of BaltimoreBaltimore, United StatesContact: Jason M. Fixler (principal investigator)Taking people
  • Eastern Maine Medical CenterBangor, United StatesTaking people
  • Walter Reed National Military Medical CenterBethesda, United StatesNo longer taking part
  • Children's Hospital of AlabamaBirmingham, United StatesContact: Matthew A. Kutny (principal investigator)Taking people
  • Saint Luke's Cancer Institute - BoiseBoise, United StatesContact: Martha M. Pacheco (principal investigator)Taking people
  • Dana-Farber Cancer InstituteBoston, United StatesContact: Jessica A. Pollard (principal investigator)Taking people
  • Maimonides Medical CenterBrooklyn, United StatesContact: Mahmut Y. Celiker (principal investigator)Taking people
  • UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesContact: Thomas B. Alexander (principal investigator)Taking people
  • Medical University of South CarolinaCharleston, United StatesContact: Jacqueline M. Kraveka (principal investigator)Taking people
  • Carolinas Medical Center/Levine Cancer InstituteCharlotte, United StatesContact: Joel A. Kaplan (principal investigator)Taking people
  • Novant Health Presbyterian Medical CenterCharlotte, United StatesContact: Holly Edington (principal investigator)Taking people
  • University of Virginia Cancer CenterCharlottesville, United StatesContact: Brian C. Belyea (principal investigator)Taking people
  • Lurie Children's Hospital-ChicagoChicago, United StatesContact: Jenna Rossoff (principal investigator)Taking people
  • University of Chicago Comprehensive Cancer CenterChicago, United StatesContact: Gabrielle Lapping-Carr (principal investigator)Taking people
  • University of IllinoisChicago, United StatesContact: Dipti S. Dighe (principal investigator)Taking people
  • Cincinnati Children's Hospital Medical CenterCincinnati, United StatesContact: Lauren Pommert (principal investigator)Taking people
  • Rainbow Babies and Childrens HospitalCleveland, United StatesContact: Duncan S. Stearns (principal investigator)Taking people
  • Cleveland Clinic FoundationCleveland, United StatesNo longer taking part
  • Prisma Health Richland HospitalColumbia, United StatesContact: Stuart L. Cramer (principal investigator)Taking people
  • University of Missouri Children's HospitalColumbia, United StatesContact: Barbara A. Gruner (principal investigator)Taking people
  • Nationwide Children's HospitalColumbus, United StatesContact: Mark A. Ranalli (principal investigator)Taking people
  • Driscoll Children's HospitalCorpus Christi, United StatesContact: Nkechi I. Mba (principal investigator)Taking people
  • Medical City Dallas HospitalDallas, United StatesContact: Maurizio L. Ghisoli (principal investigator)Taking people
  • UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesContact: Kathleen F. Ludwig (principal investigator)Taking people
  • Geisinger Medical CenterDanville, United StatesContact: Jagadeesh Ramdas (principal investigator)Taking people
  • Dayton Children's HospitalDayton, United StatesContact: Jordan M. Wright (principal investigator)Taking people
  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterDenver, United StatesContact: Florence Choo (principal investigator)Taking people
  • Blank Children's HospitalDes Moines, United StatesContact: Samantha L. Mallory (principal investigator)Taking people
  • Children's Hospital of MichiganDetroit, United StatesContact: Meret Henry (principal investigator)Taking people
  • Kaiser Permanente Downey Medical CenterDowney, United StatesContact: Robert M. Cooper (principal investigator)Taking people
  • Duke University Medical CenterDurham, United StatesContact: Jessica M. Sun (principal investigator)Taking people
  • Michigan State UniversityEast Lansing, United StatesNo longer taking part
  • El Paso Children's HospitalEl Paso, United StatesContact: Benjamin Carcamo (principal investigator)Taking people
  • Inova Fairfax HospitalFalls Church, United StatesContact: Robin Y. Dulman (principal investigator)Taking people
  • Sanford Broadway Medical CenterFargo, United StatesContact: Samuel J. Milanovich (principal investigator)Taking people
  • Broward Health Medical CenterFort Lauderdale, United StatesContact: Hector M. Rodriguez-Cortes (principal investigator)Taking people
  • Golisano Children's Hospital of Southwest FloridaFort Myers, United StatesContact: Emad K. Salman (principal investigator)Taking people
  • Cook Children's Medical CenterFort Worth, United StatesContact: Holly Pacenta (principal investigator)Taking people
  • UF Health Cancer Institute - GainesvilleGainesville, United StatesContact: Brian Stover (principal investigator)Taking people
  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, United StatesContact: Kathleen Y. Butler (principal investigator)Taking people
  • BI-LO Charities Children's Cancer CenterGreenville, United StatesContact: Aniket Saha (principal investigator)Taking people
  • East Carolina UniversityGreenville, United StatesContact: Andrea R. Whitfield (principal investigator)Taking people
  • Hackensack University Medical CenterHackensack, United StatesContact: Jing Chen (principal investigator)Taking people
  • Connecticut Children's Medical CenterHartford, United StatesContact: Michael S. Isakoff (principal investigator)Taking people
  • Penn State Children's HospitalHershey, United StatesContact: Lisa M. McGregor (principal investigator)Taking people
  • Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, United StatesContact: Iftikhar Hanif (principal investigator)Taking people
  • Kapiolani Medical Center for Women and ChildrenHonolulu, United StatesContact: Wade T. Kyono (principal investigator)Taking people
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHouston, United StatesContact: Michele S. Redell (principal investigator)Taking people
  • UT MD Anderson Cancer CenterHouston, United StatesContact: Najat C. Daw (principal investigator)Taking people
  • Ascension Saint Vincent Indianapolis HospitalIndianapolis, United StatesContact: Bassem I. Razzouk (principal investigator)Taking people
  • Riley Hospital for ChildrenIndianapolis, United StatesContact: Sandeep Batra (principal investigator)Taking people
  • University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesContact: Andrew P. Groves (principal investigator)Taking people
  • University of Mississippi Medical CenterJackson, United StatesContact: Amanda Strobel (principal investigator)Taking people
  • Nemours Children's Clinic-JacksonvilleJacksonville, United StatesContact: Sridhi Patel (principal investigator)Taking people
  • Bronson Methodist HospitalKalamazoo, United StatesContact: Kathleen Y. Butler (principal investigator)Taking people
  • Children's Mercy Hospitals and ClinicsKansas City, United StatesContact: Kevin F. Ginn (principal investigator)Taking people
  • East Tennessee Childrens HospitalKnoxville, United StatesContact: Susan E. Spiller (principal investigator)Taking people
  • Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas Vegas, United StatesContact: Alan K. Ikeda (principal investigator)Taking people
  • Summerlin Hospital Medical CenterLas Vegas, United StatesContact: Alan K. Ikeda (principal investigator)Taking people
  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, United StatesContact: Angela Ricci (principal investigator)Taking people
  • University of Kentucky/Markey Cancer CenterLexington, United StatesContact: James T. Badgett (principal investigator)Taking people
  • Arkansas Children's HospitalLittle Rock, United StatesContact: Michael W. Bishop (principal investigator)Taking people
  • Loma Linda University Medical CenterLoma Linda, United StatesContact: Albert Kheradpour (principal investigator)Taking people
  • Miller Children's and Women's Hospital Long BeachLong Beach, United StatesContact: Jacqueline N. Casillas (principal investigator)Taking people
  • Children's Hospital Los AngelesLos Angeles, United StatesContact: Jamie L. Stokke (principal investigator)Taking people
  • Norton Children's HospitalLouisville, United StatesContact: Michael J. Ferguson (principal investigator)Taking people
  • Covenant Children's HospitalLubbock, United StatesContact: Kishor M. Bhende (principal investigator)Taking people
  • UMC Cancer Center / UMC Health SystemLubbock, United StatesContact: Erin K. Barr (principal investigator)Taking people
  • Valley Children's HospitalMadera, United StatesContact: Ruetima Titapiwatanakun (principal investigator)Taking people
  • University of Wisconsin Carbone Cancer Center - University HospitalMadison, United StatesContact: Kenneth B. De SantesTaking people
  • Marshfield Medical Center-MarshfieldMarshfield, United StatesContact: Michelle A. Manalang (principal investigator)Taking people
  • Loyola University Medical CenterMaywood, United StatesContact: Eugene Suh (principal investigator)Taking people
  • Saint Jude Children's Research HospitalMemphis, United StatesContact: Seth E. Karol (principal investigator)Taking people
  • Banner Children's at DesertMesa, United StatesContact: Joseph C. Torkildson (principal investigator)Taking people
  • Nicklaus Children's HospitalMiami, United StatesContact: Maggie E. Fader (principal investigator)Taking people
  • NYU Langone Hospital - Long IslandMineola, United StatesContact: Chana L. Glasser (principal investigator)Taking people
  • Children's Hospitals and Clinics of Minnesota - MinneapolisMinneapolis, United StatesContact: Michael K. Richards (principal investigator)Taking people
  • University of Minnesota/Masonic Cancer CenterMinneapolis, United StatesContact: Peter M. Gordon (principal investigator)Taking people
  • USA Health Strada Patient Care CenterMobile, United StatesContact: Hamayun Imran (principal investigator)Taking people
  • West Virginia University HealthcareMorgantown, United StatesContact: Ashley E. Meyer (principal investigator)Taking people
  • Morristown Medical CenterMorristown, United StatesContact: Kathryn L. Laurie (principal investigator)Taking people
  • The Children's Hospital at TriStar CentennialNashville, United StatesContact: Clinton M. Carroll (principal investigator)Taking people
  • Vanderbilt University/Ingram Cancer CenterNashville, United StatesContact: Christine M. Smith (principal investigator)Taking people
  • Jersey Shore Medical CenterNeptune City, United StatesContact: Jing Chen (principal investigator)Taking people
  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University HospitalNew Brunswick, United StatesContact: Richard A. Drachtman (principal investigator)Taking people
  • Saint Peter's University HospitalNew Brunswick, United StatesContact: Nibal A. Zaghloul (principal investigator)Taking people
  • Yale UniversityNew Haven, United StatesContact: Stephanie A. Massaro (principal investigator)Taking people
  • The Steven and Alexandra Cohen Children's Medical Center of New YorkNew Hyde Park, United StatesContact: Arlene S. Redner (principal investigator)Taking people
  • Ochsner Medical Center JeffersonNew Orleans, United StatesContact: Craig Lotterman (principal investigator)Taking people
  • Children's Hospital New OrleansNew Orleans, United StatesNo longer taking part
  • Memorial Sloan-Kettering Cancer CenterNew York, United StatesContact: Maria Luisa Sulis (principal investigator)Taking people
  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, United StatesContact: Nobuko Hijiya (principal investigator)Taking people
  • Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, United StatesNo longer taking part
  • Children's Hospital of The King's DaughtersNorfolk, United StatesContact: Melissa S. Mark (principal investigator)Taking people
  • Advocate Children's Hospital-Oak LawnOak Lawn, United StatesContact: Rebecca E. McFall (principal investigator)Taking people
  • Kaiser Permanente-OaklandOakland, United StatesContact: Aarati V. Rao (principal investigator)Taking people
  • UCSF Benioff Children's Hospital OaklandOakland, United StatesContact: Jennifer G. Michlitsch (principal investigator)Taking people
  • University of Oklahoma Health Sciences CenterOklahoma City, United StatesContact: Rene Y. McNall-Knapp (principal investigator)Taking people
  • Children's Hospital and Medical Center of OmahaOmaha, United StatesContact: Jill C. Beck (principal investigator)Taking people
  • University of Nebraska Medical CenterOmaha, United StatesContact: Jill C. Beck (principal investigator)Taking people
  • Children's Hospital of Orange CountyOrange, United StatesContact: Elyssa M. Rubin (principal investigator)Taking people
  • Arnold Palmer Hospital for ChildrenOrlando, United StatesContact: Zhongbo Hu (principal investigator)Taking people
  • Nemours Children's HospitalOrlando, United StatesContact: Sridhi Patel (principal investigator)Taking people
  • Lucile Packard Children's Hospital Stanford UniversityPalo Alto, United StatesContact: Jay Michael S. Balagtas (principal investigator)Taking people
  • Advocate Children's Hospital-Park RidgePark Ridge, United StatesContact: Rebecca E. McFall (principal investigator)Taking people
  • Saint Joseph's Regional Medical CenterPaterson, United StatesContact: Alissa Kahn (principal investigator)Taking people
  • Nemours Children's Clinic - PensacolaPensacola, United StatesContact: Jeffrey H. Schwartz (principal investigator)Taking people
  • Sacred Heart HospitalPensacola, United StatesNo longer taking part
  • OSF Children's Hospital of IllinoisPeoria, United StatesContact: Prerna Kumar (principal investigator)Taking people
  • Children's Hospital of PhiladelphiaPhiladelphia, United StatesContact: Sarah K. Tasian (principal investigator)Taking people
  • Saint Christopher's Hospital for ChildrenPhiladelphia, United StatesContact: Gregory E. Halligan (principal investigator)Taking people
  • Phoenix Childrens HospitalPhoenix, United StatesContact: Dana B. Salzberg (principal investigator)Taking people
  • Children's Hospital of Pittsburgh of UPMCPittsburgh, United StatesContact: Erika Friehling (principal investigator)Taking people
  • Legacy Emanuel Children's HospitalPortland, United StatesContact: Jason M. Glover (principal investigator)Taking people
  • Oregon Health and Science UniversityPortland, United StatesContact: Bill H. Chang (principal investigator)Taking people
  • Rhode Island HospitalProvidence, United StatesContact: Bradley DeNardo (principal investigator)Taking people
  • Renown Regional Medical CenterReno, United StatesContact: Alan K. Ikeda (principal investigator)Taking people
  • VCU Massey Comprehensive Cancer CenterRichmond, United StatesContact: Jordyn R. Griffin (principal investigator)Taking people
  • Carilion Children'sRoanoke, United StatesContact: Erwood G. Edwards (principal investigator)Taking people
  • Mayo Clinic in RochesterRochester, United StatesContact: Wendy Allen-Rhoades (principal investigator)Taking people
  • University of RochesterRochester, United StatesNo longer taking part
  • Corewell Health Children'sRoyal Oak, United StatesContact: Marie V. Nelson (principal investigator)Taking people
  • Primary Children's HospitalSalt Lake City, United StatesContact: David S. Mangum (principal investigator)Taking people
  • Children's Hospital of San AntonioSan Antonio, United StatesContact: Julie Voeller (principal investigator)Taking people
  • Methodist Children's Hospital of South TexasSan Antonio, United StatesContact: Jose M. Esquilin (principal investigator)Taking people
  • University of Texas Health Science Center at San AntonioSan Antonio, United StatesContact: Allison C. Grimes (principal investigator)Taking people
  • Rady Children's Hospital - San DiegoSan Diego, United StatesContact: William D. Roberts (principal investigator)Not yet recruiting
  • UCSF Medical Center-Mission BaySan Francisco, United StatesContact: Elliot Stieglitz (principal investigator)Taking people
  • Memorial Health University Medical CenterSavannah, United StatesContact: Andrew L. Pendleton (principal investigator)Taking people
  • Maine Children's Cancer ProgramScarborough, United StatesContact: Sei-Gyung K. Sze (principal investigator)Taking people
  • Seattle Children's HospitalSeattle, United StatesContact: Sarah E. Leary (principal investigator)Taking people
  • Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesContact: Jordan Fritch-Hanson (principal investigator)Taking people
  • Providence Sacred Heart Medical Center and Children's HospitalSpokane, United StatesContact: Judy L. Felgenhauer (principal investigator)Taking people
  • Southern Illinois University School of MedicineSpringfield, United StatesContact: Gregory P. Brandt (principal investigator)Taking people
  • Cardinal Glennon Children's Medical CenterSt Louis, United StatesContact: William S. Ferguson (principal investigator)Taking people
  • Mercy Hospital Saint LouisSt Louis, United StatesContact: Robin D. Hanson (principal investigator)Taking people
  • Washington University School of MedicineSt Louis, United StatesContact: Laura G. Schuettpelz (principal investigator)Taking people
  • Johns Hopkins All Children's HospitalSt. Petersburg, United StatesContact: Jennifer L. Mayer (principal investigator)Taking people
  • Stony Brook University Medical CenterStony Brook, United StatesContact: Laura E. Hogan (principal investigator)Taking people
  • State University of New York Upstate Medical UniversitySyracuse, United StatesContact: Melanie A. Comito (principal investigator)Taking people
  • Madigan Army Medical CenterTacoma, United StatesContact: Melissa A. Forouhar (principal investigator)Taking people
  • Mary Bridge Children's Hospital and Health CenterTacoma, United StatesContact: Robert G. Irwin (principal investigator)Taking people
  • Saint Joseph's Hospital/Children's Hospital-TampaTampa, United StatesContact: Don E. Eslin (principal investigator)Taking people
  • Montefiore Medical Center - Moses CampusThe Bronx, United StatesContact: Alice Lee (principal investigator)Taking people
  • ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalToledo, United StatesContact: Jamie L. Dargart (principal investigator)Taking people
  • Banner University Medical Center - TucsonTucson, United StatesContact: Monica M. Davini (principal investigator)Taking people
  • New York Medical CollegeValhalla, United StatesContact: Andrew J. Bellantoni (principal investigator)Taking people
  • Children's National Medical CenterWashington D.C., United StatesContact: Jeffrey S. Dome (principal investigator)Taking people
  • MedStar Georgetown University HospitalWashington D.C., United StatesNo longer taking part
  • Saint Mary's Medical CenterWest Palm Beach, United StatesContact: Matthew D. Ramirez (principal investigator)Taking people
  • Alfred I duPont Hospital for ChildrenWilmington, United StatesContact: Sridhi Patel (principal investigator)Taking people
  • Northwestern Medicine Central DuPage HospitalWinfield, United StatesContact: Jenna Rossoff (principal investigator)Taking people
  • Wake Forest University Health SciencesWinston-Salem, United StatesContact: Sarah Supples (principal investigator)Taking people

About the trial

What the trial wants to find out

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

The group in the trial

  • Screening (biospecimen collection)Treatment being tested

    Patients undergo collection of blood and/or bone marrow samples at baseline, end of treatment cycle(s), and at relapse/refractory disease status (if applicable).

    Treatment: Biospecimen Collection

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias
Plain-language title
Testing bone marrow and blood in children with relapsed or hard-to-treat leukemiaGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
25 August 2026