Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
Key facts
- Where
- Manhasset, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT04758624, who can take part
Where in United States
- North Shore University HospitalManhasset, United StatesContact: Albert FenoyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Northwell Health
- Trial code
- NCT04758624
- Record updated
- 29 September 2026
- Original description
The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulationRead full original descriptionShow less
The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation
Inclusion: the diagnosis of Essential Tremor, made by a movement disorder neurologist, where tremor is not secondary to any disease process or traumatic insult; distal appendicular tremor, with minimal proximal component; tremor refractory to multiple medication regimens and/or where the medications cause intolerable side effects; tremor judged to be severely impacting their quality of life.
Exclusion: previous surgery to destroy the target region of the brain; surgical contraindications to DBS; significant neurological disorder; significant dementia or neurocognitive limitations as assessed by neuropsychiatry (when necessary); severe psychiatric illness with suicidal ideations; current major medical problems that affect brain anatomy,neurochemistry, or function, e.g., liver insufficiency, kidney insufficiency, cardiovascular problems, systemic infections, cancer, hypothyroidism, auto-immune diseases, and any current of history of brain disorder (seizure disorder, stroke, dementia, meningitis, encephalitis, degenerative neurologic diseases and head injury with loss of consciousness for any period of time); family history of hereditary neurologic disorder, besides essential tremors ET; floating metallic objects in the body; pregnancy; alcohol or substance abuse/dependence in the past 6 months.