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Deep brain stimulation and brain connections in essential tremor

Studies how deep brain stimulation changes brain networks in people with essential tremor.

Key facts

Who runs it
Northwell Health
Where
Manhasset, United StatesSee the site
Trial code
Registry title
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
Status
Recruiting
People taking part
72 people, planned
Started
4 Dec 2021
Expected to end
31 Aug 2027
Type of study
Interventional
Treatments tested
  • Deep Brain Stimulation
Record updated
29 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with essential tremor that medicines do not control well. Participants receive deep brain stimulation (DBS) and have brain connection studies.

Age
18 Years to 85 Years
Sex
All
Disease stage
Essential tremor diagnosed by a movement disorder neurologist, not caused by another disease or injury. Tremor mainly in the hands or lower arms, with little shaking near the shoulders. Tremor severely affects quality of life.
Earlier treatment
Tremor has not improved with several medicine plans, or the medicines caused side effects that could not be tolerated. People who had surgery to destroy the target brain area cannot join.

Main reasons for not taking part

  • Significant neurological disorder, dementia, or other brain disorder now or in the past
  • Severe psychiatric illness with suicidal thoughts
  • Medical reasons that rule out DBS surgery, or loose metal objects in the body
  • Major medical problems such as liver or kidney failure, heart problems, cancer, or autoimmune disease
  • Pregnancy, or alcohol or drug abuse in the past 6 months

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • the diagnosis of Essential Tremor, made by a movement disorder neurologist, where tremor is not secondary to any disease process or traumatic insult
  • distal appendicular tremor, with minimal proximal component
  • tremor refractory to multiple medication regimens and/or where the medications cause intolerable side effects
  • tremor judged to be severely impacting their quality of life

Who cannot take part

  • previous surgery to destroy the target region of the brain
  • surgical contraindications to DBS
  • significant neurological disorder
  • significant dementia or neurocognitive limitations as assessed by neuropsychiatry (when necessary)
  • severe psychiatric illness with suicidal ideations
  • current major medical problems that affect brain anatomy,neurochemistry, or function, e.g., liver insufficiency, kidney insufficiency, cardiovascular problems, systemic infections, cancer, hypothyroidism, auto-immune diseases, and any current of history of brain disorder (seizure disorder, stroke, dementia, meningitis, encephalitis, degenerative neurologic diseases and head injury with loss of consciousness for any period of time)
  • family history of hereditary neurologic disorder, besides essential tremors ET
  • floating metallic objects in the body
  • pregnancy
  • alcohol or substance abuse/dependence in the past 6 months

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 85 years old?

Where in United States

  • North Shore University HospitalManhasset, United StatesContact: Albert FenoyTaking people

About the trial

What the trial wants to find out

The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation

The group in the trial

  • Deep Brain Stimulation(DBS)Treatment being tested

    Treatment: Deep Brain Stimulation

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
Plain-language title
Deep brain stimulation and brain connections in essential tremorGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Fit questions
Built from NCT04758624, who can take part
Record updated
29 September 2026