Frontlight ResearchEarly access
CompletedNo phase
AESOPS Trial 2 (AESOPS-2): Availability of Opioid Harm
Key facts
- Who runs it
- University of Southern California
- Where
- Chicago, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 61 people enrolled
- Started
- 23 Jan 2023
- Ended
- 18 Mar 2024
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Overdose Notification
- Record updated
- 7 October 2025
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- 1) The clinician prescribed a qualifying scheduled drug to a patient in the 12 months prior to their non-fatal or fatal overdose 2) the patient is 18 years old or older at the time of the overdose, 3) the provider practices within a health system enrolled in the study, and 4) the overdose occurs during the 12-month observation period. Qualifying prescriptions include those for one of the following scheduled drugs: opioids, benzodiazepines, muscle relaxants or sedative-hypnotics
Who cannot take part
- Prescriptions to patients in hospice or with active cancer
Where in United States
- Northwestern UniversityChicago, United States
About the trial
What the trial wants to find out
The opioid epidemic is the largest man-made public health crisis the United States has faced. The objective of Trial 2 of the Application of Economics \& Social psychology to improve Opioid Prescribing Safety (AESOPS-2) study, is to discourage unnecessary opioid prescribing by increasing the salience of negative patient outcomes associated with opioid use.
The 2 groups in the trial
- Control GroupNo study treatment, for comparison
Physicians in the control group will receive no notification of their patient's fatal or nonfatal overdose.
- Overdose Notification GroupTreatment being tested
The overdose notifications will alert prescribers to the patient's opioid-related overdose, recommend the use of the state-level PDMP, and list evidence-based interventions to lower opioid-related overdoses.
Treatment: Overdose Notification
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 2 (AESOPS-2): Availability of Opioid Harm
- Record updated
- 7 October 2025