Phone App Helps Guide Water Pill Doses for Swelling in Kidney Disease
Tests a phone app that guides daily water pill doses for swelling in adults.
Plain-language title generated from the registry record
Registry title: Diuretic Tuner Clinical Decision Support
Key facts
- Where
- Dallas, United StatesSee the site
Where in United States
- University of Texas, SouthwesternDallas, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Texas Southwestern Medical Center
- Trial code
- NCT04759274
- Record updated
- 29 October 2026
- Original description
This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing.Read full original descriptionShow less
Diuretic Tuner Clinical Decision Support Mobile Device Application for Diuretic Titration in Hypervolemic States
This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing.
Participants in this study will have an application loaded on to their mobile phone by the study team and be taught how to use it over a 2 hour visit. Participants will need to check their blood pressure and weight daily and enter this information into the mobile phone application every day. Participants will need to follow daily instructions in their medication dosing provided by the application. There will be periodic blood testing. This will happen at 2 weeks, 90 days, and up to 4 other times if necessary. At the end of the study there is a 2 hour study visit during which participants will answer a survey. The total length of the study is 90 days.
Inclusion: The presence of nephrotic range proteinuria (> 3 g/d proteinuria by 24hr urine protein, 24hr urine albumin, spot urine protein/creatinine ratio, or spot urine albumin/creatinine ratio) or stage 4 or 5 chronic kidney disease (estimated glomerular filtration rate < 30 mL/min/1.73 m2 by Modification of Diet in Renal Disease equation) PLUS; Clinical signs of hypervolemia present (lower extremity edema, ascites, or pleural effusions) with an estimated dry weight (defined as edema-free weight without orthostatic hypotension) 5 lbs less than enrollment body weight.
Exclusion: Autonomic insufficiency resulting in orthostatic hypotension at screening; The presence of a medical condition that would interfere with effectively using the Diuretic Tuner (dementia, illiteracy, or blindness); Hypokalemia at enrollment (defined as serum potassium < 3.5 mmol/L); Moderate to severe hyponatremia at enrollment (defined as serum sodium < 130 mmol/L); Serum creatinine > 6 mg/dL or > 1.5 times baseline; Weight < 100 lbs or > 300 lbs; Patients who are unable or unwilling to measure their home blood pressures and weights; Patients without a working phone number and smart phone device; Expectation that the patient will require dialysis initiation within < 3 months; Expected lifespan of < 6 months; Pregnant patients; Prisoners.