Tests terazosin for dementia with Lewy bodies
Tests whether terazosin is tolerated by people with dementia with Lewy bodies, compared with placebo.
Plain-language title generated from the registry record
Registry title: Terazosin for Dementia With Lewy Bodies
Key facts
- Where
- Iowa City, United StatesSee the site
- Phase
- Phase 1/2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 0 and 90 years old?
Source: NCT04760860, who can take part
Where in United States
- University of IowaIowa City, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Qiang Zhang
- Trial code
- NCT04760860
- Record updated
- 12 March 2026
- Original description
The TZ-DLB trial will be a 3:2 (active:placebo) randomized, double-blind, placebo-controlled Pilot trial to evaluate the tolerability of terazosin for the treatment of dementia with Lewy bodies.Read full original descriptionShow less
a Randomized, Double Blind, Placebo Controlled Clinical Trial Exploring the Target Engagement and Tolerability of Terazosin Hydrochloride in Patients With Dementia With Lewy Bodies
The TZ-DLB trial will be a 3:2 (active:placebo) randomized, double-blind, placebo-controlled Pilot trial to evaluate the tolerability of terazosin for the treatment of dementia with Lewy bodies.
Inclusion: Men or women with the diagnosis of dementia with Lewy Bodies per 2017 DLB Consortium criteria; Baseline MOCA 18 or above. On stable AChEI and/or memantine treatment regimen for ≥4 weeks prior to baseline.
Exclusion: Psychiatric comorbidities including major depression, bipolar affective disorder, or other mental health disorders that are sufficiently severe to increase adverse event risk or impact neurology assessment in the opinion of the responsible site principal investigator. Subjects with clinically significant depression as determined by a Beck Depression Inventory score greater than 21 at the screening visit. Current suicidal ideation within one year prior to the baseline visit as evidenced by answering "yes" to Questions 4 or 5 on the suicidal ideation portion of the Columbia-Suicide Severity Rating Scale (C-SSRS) If the participant has a Beck Anxiety Score greater than 22 at the initial screening visit; Use of investigational drugs within 30 days before screening; Subjects have to be on a stable regimen of central nervous system acting medications (benzodiazepines, antidepressants, hypnotics) for 30 days prior to the baseline visit; Clinically significant traumatic brain injury or post-traumatic stress disorder; No confounding acute or unstable medical, psychiatric, orthopedic condition. Subjects who have hypertension, diabetes mellitus, depression, or other common age-related illness will be included if their disease under control with stable treatment regimen for at least 30 days; Subjects unwilling or unable to give informed consent; Orthostatic hypotension defined as symptomatic decrease in BP > 20mmHg systolic or > 10mmHg diastolic on supine to sitting or standing, or a sitting blood pressure of ≤90/60; Presence of other known medical comorbidities that in the investigator's opinion would compromise participation in the study; Use of doxazosin, alfuzosin, prazosin, or tamsulosin; For female participant, pregnancy, or plans for child-bearing during study period; Participant is restricted from traveling to and from the study site.