Breathing muscle training for people after a lung transplant
Tests training of breathing-in muscles in adults after a lung transplant.
Key facts
- Who runs it
- Mayo Clinic
- Where
- Jacksonville, United StatesSee the site
- Trial code
- Registry title
- Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant
- Status
- Recruiting
- People taking part
- 30 people, planned
- Started
- 10 May 2021
- Expected to end
- Dec 2027
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- POWERBreathe Plus®
- Cardiopulmonary rehabilitation post lung transplant
- Record updated
- 6 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who have a single- or double-lung transplant at Mayo Clinic Florida. It studies breathing-muscle training after the transplant.
- Age
- 18 Years and older
- Sex
- All
- Disease stage
- People who have a single- or double-lung transplant at Mayo Clinic Florida.
- Earlier treatment
- A single- or double-lung transplant at Mayo Clinic Florida. People getting a second transplant cannot join.
Main reasons for not taking part
- Not surviving the transplant surgery
- Getting a second (repeat) transplant
- Getting a transplant of more than one organ
- Not willing or not able to give written consent
This trial only enrols participants who have had an organ transplant. The registry sentence this rests on: - All patients who undergo single- or double-lung transplant at Mayo Clinic Florida.
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- All patients who undergo single- or double-lung transplant at Mayo Clinic Florida
Who cannot take part
- Patients who do not survive the intra-operative period during the transplant surgery
- Patients undergoing multiorgan transplantation
- Patients undergoing retransplantation
- Patients who are not willing to or who are unable to give written informed consent
Where in United States
- Mayo Clinic in FloridaJacksonville, United StatesContact: Temetria MillerTaking people
About the trial
What the trial wants to find out
The purpose of this research is to study the effect of training the inspiratory muscles (i.e. the muscle that allow you to breath-in) on exercise capacity, quality of life, and short-term clinical outcomes in patients post lung transplant.
The 2 groups in the trial
- 12-weeks pulmonary rehabilitation training plus inspiratory muscle trainingTreatment being tested
To assess maximum inspiratory pressure, you will be asked to breathe through a device called POWERBreathe Plus®. This device is commercially available and will be provided to you by the study. You will be asked to use this device twice per day, 5 days per week, for 12 weeks. Each session will require you to breathe into the device 30 times. You can use the device at home.
Treatment: POWERBreathe Plus® and Cardiopulmonary rehabilitation post lung transplant
- 12-weeks pulmonary rehabilitation plus placebo (inactive) inspiratory musclePlacebo, for comparison
To assess maximum inspiratory pressure with placebo, you will be asked to breathe through a device called POWERBreathe Plus®. This device is commercially available and will be provided to you by the study. You will be asked to use this device twice per day, 5 days per week, for 12 weeks. Each session will require you to breathe into the device 30 times. You can use the device at home. The resistance will be set to about 5% throughout the study.
Treatment: POWERBreathe Plus® and Cardiopulmonary rehabilitation post lung transplant
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant: A Randomized Controlled Trial
- Plain-language title
- Breathing muscle training for people after a lung transplantGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 6 January 2026