Studying bone fracture in patients with osteoporosis using imaging and computer models
Observes bone damage in people with osteoporosis who are having hip replacement surgery.
Plain-language title generated from the registry record
Registry title: Image-guided Computational and Experimental Analyses of Fractured Patient's Bone (GAP)
Key facts
- Where
- Miano, ItalySee the site
Where in Italy
- IRCCS Istituto Ortopedico GaleazziMiano, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Laura Maria Vergani
- Trial code
- NCT04787679
- Record updated
- 29 January 2026
- Original description
Due to the increase in the average age of the population, the projections on the number of age-dependent bone fractures appear to be constantly increasing.Read full original descriptionShow less
Image-guided Computational and Experimental Analyses of Fractured Patient's Bone (GAP)
Due to the increase in the average age of the population, the projections on the number of age-dependent bone fractures appear to be constantly increasing.
They are mainly due to bone pathologies, including osteoporosis. The latter leads to a reduction in bone mineral density and deterioration of the micro-architecture, with a consequent increase in bone fragility. However, the mechanisms of damage at the micro-scale have not yet been elucidated and there is no universally recognized damage criterion. Recent research has evaluated the importance of implementing computational models to study the influence of bone gaps, canaliculi and microporosities on the propagation of damage. These models need to be validated through experimental tests, still lacking, in particular on human bones, in the current scientific landscape. Once the experimental validation of computational models has been developed, it will be possible to introduce new fracture indices at the micro-scale, useful for a preventive diagnosis of osteoporosis.
Inclusion: Age: >=18 years; primary hip replacement; Signature of informed consent; Patients who have a routine preoperative CT scan.
Exclusion: Bone disease (non-osteoporotic) such as to invalidate sample analysis, including but not limited to genetic disorders and bone tumors; Patients unrelated to the inclusion criteria of this study; Patients with contralateral hip replacement and/or other synthetic means in the contralateral hip; Patients with synthesis devices in the hip of interest.