Meals to Improve Absorption of Iron Supplements
Key facts
- Who runs it
- Pennington Biomedical Research Center
- Where
- Baton Rouge, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 59 people enrolled
- Started
- 10 May 2021
- Ended
- 1 Nov 2024
- Type of study
- Interventional, 2 groups
- Treatments tested
- Iron supplement with a lunch meal containing beef
- Iron supplement with a lunch meal containing plant-based alternative
- Record updated
- 7 February 2025
Who can take part
- Age
- 18 years to 40 years
- Sex
- Women only
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Body mass index (BMI) falls within the normal weight or overweight range (18.5-29.9 kg/m\^2)
- Low iron stores (serum ferritin <25 μg/L)
- Willing to refrain from smoking and >2 alcoholic drinks/week for the duration of the study period
- Willing to refrain from vitamin and mineral supplementation for the duration of the study
Who cannot take part
- Currently taking a medication that interferes with micronutrient metabolism
- History of any disease or abnormality of the gastrointestinal tract including, but not limited to, diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis; or previous gastrointestinal surgery
- Metabolic or cardiovascular abnormalities (e.g., kidney disease, diabetes, cardiovascular disease, etc.)
- Currently smoking or vaping
- Unwilling to refrain from vitamin and mineral supplementation for the duration of the study
- Restrictive diets (i.e., vegan or vegetarian diets)
- Blood donation within 4 months of beginning the study
- Abnormal blood clotting
Where in United States
- Pennington Biomedical Research CenterBaton Rouge, United States
About the trial
What the trial wants to find out
One of the targeted objectives of Healthy People 2020 is to reduce iron deficiency among women of reproductive age (WRA). Consuming foods rich in iron and/or oral iron supplementation is typically recommended to improve iron status; however, global rates of iron deficiency remain high. Thus, nutritional strategies to improve/maintain iron status are warranted. Dietary iron is found in two different forms: heme and non-heme iron. Non-heme iron is found in plant-based sources and is commonly used as a supplement and food fortificant. Absorption of non-heme iron is low compared to heme iron, which is found in animal sources, such as beef. Studies have also demonstrated that beef contains an unidentified factor that stimulates the absorption of non-heme iron. The primary objective of the proposed study is to determine the effects of incorporating daily meals containing beef or plant-based alternative with or without an iron supplement on indicators of iron status in iron-deficient WRA.
The 2 groups in the trial
- BeefTreatment being tested
Treatment: Iron supplement with a lunch meal containing beef
- Plant-based alternativeTreatment being tested
Treatment: Iron supplement with a lunch meal containing plant-based alternative
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Meals to Improve Absorption of Iron Supplements and Iron Status in Iron Deficient Women of Reproductive Age: a Randomized, Controlled Trial
- Publications
- Higher Lipoprotein(a) Concentration Is Associated with a Blunted Response to Iron Repletion in Females with Low Iron Stores: A Secondary Analysis of a Randomized Controlled Trial.The Journal of nutrition, 2026
- Improved Iron Status, but Not Protein Source, Is Related to Appetite, Satiety, and Mood in Women of Reproductive Age With Iron Deficiency: A Randomized Controlled Trial.The Journal of nutrition, 2026
- Daily Consumption of Beef, Compared to Plant-Based Meat, for Eight Weeks Has No Effects on Cardiometabolic Risk Factors among Women of Reproductive Age with Low Iron Stores: A Randomized, Controlled Clinical Trial.The Journal of nutrition, 2025
- Effects of consuming an iron supplement with a meal containing animal or plant-based meat on indicators of iron status and anemia in women of reproductive age with iron deficiency: a randomized, controlled study.The American journal of clinical nutrition, 2025
- Record updated
- 7 February 2025