Sign in
CompletedNo phase

Meals to Improve Absorption of Iron Supplements

Key facts

Who runs it
Pennington Biomedical Research Center
Where
Baton Rouge, United StatesSee the site
Trial code
Status
Completed
People taking part
59 people enrolled
Started
10 May 2021
Ended
1 Nov 2024
Type of study
Interventional, 2 groups
Treatments tested
  • Iron supplement with a lunch meal containing beef
  • Iron supplement with a lunch meal containing plant-based alternative
Record updated
7 February 2025

Who can take part

Age
18 years to 40 years
Sex
Women only
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Body mass index (BMI) falls within the normal weight or overweight range (18.5-29.9 kg/m\^2)
  • Low iron stores (serum ferritin <25 μg/L)
  • Willing to refrain from smoking and >2 alcoholic drinks/week for the duration of the study period
  • Willing to refrain from vitamin and mineral supplementation for the duration of the study

Who cannot take part

  • Currently taking a medication that interferes with micronutrient metabolism
  • History of any disease or abnormality of the gastrointestinal tract including, but not limited to, diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis; or previous gastrointestinal surgery
  • Metabolic or cardiovascular abnormalities (e.g., kidney disease, diabetes, cardiovascular disease, etc.)
  • Currently smoking or vaping
  • Unwilling to refrain from vitamin and mineral supplementation for the duration of the study
  • Restrictive diets (i.e., vegan or vegetarian diets)
  • Blood donation within 4 months of beginning the study
  • Abnormal blood clotting

Where in United States

  • Pennington Biomedical Research CenterBaton Rouge, United States

About the trial

What the trial wants to find out

One of the targeted objectives of Healthy People 2020 is to reduce iron deficiency among women of reproductive age (WRA). Consuming foods rich in iron and/or oral iron supplementation is typically recommended to improve iron status; however, global rates of iron deficiency remain high. Thus, nutritional strategies to improve/maintain iron status are warranted. Dietary iron is found in two different forms: heme and non-heme iron. Non-heme iron is found in plant-based sources and is commonly used as a supplement and food fortificant. Absorption of non-heme iron is low compared to heme iron, which is found in animal sources, such as beef. Studies have also demonstrated that beef contains an unidentified factor that stimulates the absorption of non-heme iron. The primary objective of the proposed study is to determine the effects of incorporating daily meals containing beef or plant-based alternative with or without an iron supplement on indicators of iron status in iron-deficient WRA.

The 2 groups in the trial

  • BeefTreatment being tested

    Treatment: Iron supplement with a lunch meal containing beef

  • Plant-based alternativeTreatment being tested

    Treatment: Iron supplement with a lunch meal containing plant-based alternative

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Meals to Improve Absorption of Iron Supplements and Iron Status in Iron Deficient Women of Reproductive Age: a Randomized, Controlled Trial
Publications
Record updated
7 February 2025