Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study
Key facts
- Who runs it
- University Hospital, Rouen
- Where
- France1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Terminated
- People taking part
- 9 people enrolled
- Started
- 8 Sept 2021
- Ended
- 8 Sept 2025
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- physical activity program (APA)
- Record updated
- 8 June 2026
- Why it stopped
- Diffiulty in enrolling patients
Who can take part
- Age
- 18 years and older
- Sex
- Women only
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Female
- Patient > 18 years
- Follow-up in the department of clinical Nutrition of Rouen
- BMI ≥15,0 and <18,5 kg/m²
- Diagnosis of anorexia nervosa according to DSM-V classification
Who cannot take part
- Physical activity contraindications : hemodynamic disorder, uncontrolled cardiovascular disease, intracranial hypertension
- Patients with poor understanding of spoken or written French
- Person deprived of their liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults
- Person subject to a safeguard of justice, guardianship or curatorship
- Pregnant or breastfeeding woman
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial. Many studies suggest beneficits of APA in AN on body composition (increase fat free mass and better distribution of fat mass), mood regulation, bone metabolism. We recently reported benefits of maintaining physical activity during refeeding in a mice model of anorexia (activity-based anorexia model). These benefits involved the tryptophan-kynurenin pathway. Thus, we aim in the APANOR study to assess effects of APA during refeeding in AN on kynurenin metabolism.
The 2 groups in the trial
- Without adapted physical activity program (APA)Existing treatment, for comparison
Treatment: physical activity program (APA)
- With adapted physical activity program (APA)Treatment being tested
Treatment: physical activity program (APA)
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 8 June 2026