Studying Heart Blood Flow Problems Without Blocked Coronary Arteries
Tests heart blood vessel function in adults with heart ischemia but no major blockage.
Plain-language title generated from the registry record
Registry title: Myocardial Ischemia Without Obstructive Coronary Stenoses
Key facts
- Where
- Madrid, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who can have an invasive heart-vessel test with adenosine and/or acetylcholine, to study heart ischemia without blocked main coronary arteries.
- Age
- 18 years or older
- Sex
- All sexes can join
Main reasons for not taking part
- Unstable blood circulation (hemodynamic instability)
- Expected technical problems with the pressure wire measurements
- Culprit vessel of an acute coronary syndrome
- Cannot receive adenosine or acetylcholine
- Life expectancy of less than 1 year
Read by machine on 9 November 2026.
Where in Spain
- Hospital Clínico San CarlosMadrid, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospital San Carlos, Madrid
- Trial code
- NCT04827498
- Record updated
- 26 April 2021
- Original description
Coronary-related myocardial ischemia can result from obstructive epicardial stenosis or non-obstructive causes including coronary microcirculatory dysfunction and vasomotor disorders. This prospective study has been created in order to provide knowledge in the field of non-obstructive coronary artery disease.Read full original descriptionShow less
Myocardial Ischemia Without Obstructive Coronary Stenoses: A Prospective Observational Study With Invasive Coronary Pressure and Flow Measurements and Endothelial Function Test
Coronary-related myocardial ischemia can result from obstructive epicardial stenosis or non-obstructive causes including coronary microcirculatory dysfunction and vasomotor disorders. This prospective study has been created in order to provide knowledge in the field of non-obstructive coronary artery disease.
Inclusion: Written informed consent available; Age ≥ 18 years; Patient eligible for invasive physiological assessment with adenosine and / or acetylcholine.
Exclusion: Culprit vessel of acute coronary syndrome; Hemodynamic instability; Anticipated technical issues for physiology wire measurements; Contraindications for adenosine administration; Contraindications for acetylcholine test; Reduced life expectancy (less than 1 year).