Directional Versus Nondirectional DBS for ET
Key facts
- Where
- Portland, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT04828798, who can take part
Where in United States
- Oregon Health Science UniversityPortland, United StatesContact: Zoe FanningTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Oregon Health and Science University
- Trial code
- NCT04828798
- Record updated
- 30 October 2025
- Original description
This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and minimizes effects on speech, gait and balance compared to nondirectional DBS.Read full original descriptionShow less
Directional Versus Nondirectional Deep Brain Stimulation of the VIM Thalamic Nucleus for Essential Tremor: Assessment of Therapeutic Window, Speech, Gait and Balance
This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and minimizes effects on speech, gait and balance compared to nondirectional DBS.
Inclusion: A tremor syndrome of bilateral upper limb action tremor with at least 3 years' duration.
Exclusion: Patients who have decided not to receive DBS for control of their medication-refractory essential tremor; Prior history of deep brain stimulation; Prior history of thalamotomy; Patients with secondary tremor (ie not Essential Tremor), such as side effects from medications, secondary to another identified neurologic disease (eg multiple sclerosis, -----Parkinson's disease, dystonia); Patients with cardiac pacemakers, defibrillators, or neurostimulators; Subjects with other type of neurological disease or injury; A history or signs of dystonia, ataxia or parkinsonism; Task specific tremor; Orthostatic tremor; Patients who require MRI, ECT, rTMS, or diathermy.